J1JRX3 · J1JRX3_BARVI

Function

function

Maintains high levels of reduced glutathione.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per subunit.

Features

Showing features for binding site, active site.

146350100150200250300350400450
TypeIDPosition(s)Description
Binding site52FAD (UniProtKB | ChEBI)
Binding site177-184NAD+ (UniProtKB | ChEBI)
Binding site264NAD+ (UniProtKB | ChEBI)
Binding site305NAD+ (UniProtKB | ChEBI)
Active site438Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionglutathione-disulfide reductase (NADPH) activity
Molecular FunctionNADP binding
Biological Processcell redox homeostasis
Biological Processcellular response to oxidative stress
Biological Processglutathione metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glutathione reductase
  • EC number
  • Short names
    GRase

Gene names

    • ORF names
      ME1_01199

Organism names

Accessions

  • Primary accession
    J1JRX3

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond43↔48Redox-active

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-319FAD/NAD(P)-binding
Domain341-448Pyridine nucleotide-disulphide oxidoreductase dimerisation

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    463
  • Mass (Da)
    50,841
  • Last updated
    2012-10-03 v1
  • Checksum
    D0A9A08578385806
MRSFDFDLFVIGSGSGGVRAARLAGGLGKRVAIAEEYRVGGTCVIRGCVPKKLYVYASQYAKEFRKSVGFGWQYADPVFSWEKLVAAKNTEISRLEGLYRKGLQDNNVHIYESRASFVDDHTLELSGTGERVSAEKILIATGAKIAPNTAIKGSDMCLTSNEIFDLEKLPKSIVIVGGGYIGVEFANIFHELGVKTILLHRGDLILRNFDYDLRQLLHDAMVEKGISIIYGAAVSKIQASGNCYDVILSSGQTITTDQVMLATGRVPNTTGLKLERAGVKVNEFGAVVVDERMTTNVPHIWAVGDVTGHVQLTPVAIHDAMCFVKTAFENIPTTPDYDLITTAVFSQPEIGTVGLSEEDALHRYKRLEIYRTVFRPMRNVLSGSSEKMFMKLIVDGESRIVVGAHILGENAGEIAQLIGISLKGKLTKDIFDETMAVHPTIAEEIVTMYKPSYIYENGKKIEN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AILZ01000030
EMBL· GenBank· DDBJ
EJF87597.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp