J0QEI2 · J0QEI2_9HYPH
- ProteinHeme A synthase
- GenectaA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids361 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
Catalytic activity
- Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2This reaction proceeds in the forward direction.
Cofactor
Pathway
Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor | |
Biological Process | heme A biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHeme A synthase
- EC number
- Short namesHAS
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Bartonellaceae > Bartonella
Accessions
- Primary accessionJ0QEI2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 27-46 | Helical | ||||
Sequence: VWLYSILLLCLAIVLVGGAT | ||||||
Transmembrane | 110-128 | Helical | ||||
Sequence: ILGRLVGLVALFGLIWFWI | ||||||
Transmembrane | 140-163 | Helical | ||||
Sequence: LTIVPILIAVQGAIGWWMVASGIG | ||||||
Transmembrane | 175-193 | Helical | ||||
Sequence: LAFHLITACFVIIFVTYLS | ||||||
Transmembrane | 214-234 | Helical | ||||
Sequence: WLVILILLEIYFGALVAGLHA | ||||||
Transmembrane | 272-292 | Helical | ||||
Sequence: FIHRFFAYFLFVTAVIHALYV | ||||||
Transmembrane | 304-323 | Helical | ||||
Sequence: RAFFMCIMIAVQALLGIVTL | ||||||
Transmembrane | 329-348 | Helical | ||||
Sequence: ISLGLIHQSIALAILCFSVA |
Keywords
- Cellular component
Interaction
Subunit
Interacts with CtaB.
Structure
Family & Domains
Sequence similarities
Belongs to the COX15/CtaA family. Type 2 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length361
- Mass (Da)40,985
- Last updated2012-10-03 v1
- ChecksumA6BA21FFE06EE79F
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AILU01000004 EMBL· GenBank· DDBJ | EJF81234.1 EMBL· GenBank· DDBJ | Genomic DNA |