J0QEI2 · J0QEI2_9HYPH

Function

function

Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Pathway

Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site274Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue
Binding site335Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionmetal ion binding
Molecular Functionoxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
Biological Processheme A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Heme A synthase
  • EC number
  • Short names
    HAS
  • Alternative names
    • Cytochrome aa3-controlling protein

Gene names

    • Name
      ctaA
    • ORF names
      MCQ_00463

Organism names

Accessions

  • Primary accession
    J0QEI2

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane27-46Helical
Transmembrane110-128Helical
Transmembrane140-163Helical
Transmembrane175-193Helical
Transmembrane214-234Helical
Transmembrane272-292Helical
Transmembrane304-323Helical
Transmembrane329-348Helical

Keywords

Interaction

Subunit

Interacts with CtaB.

Family & Domains

Sequence similarities

Belongs to the COX15/CtaA family. Type 2 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    361
  • Mass (Da)
    40,985
  • Last updated
    2012-10-03 v1
  • Checksum
    A6BA21FFE06EE79F
MGQSEMAVKSKSILTSLQKKNRKQIQVWLYSILLLCLAIVLVGGATRLTGSGLSITEWKPIHGVIPPIGVEQWQEEFSKYQQIAQYKLLNHDMTLSAFKVIFWWEWAHRILGRLVGLVALFGLIWFWITKRIEKNILLQLTIVPILIAVQGAIGWWMVASGIGQSTLTSVSQYRLAFHLITACFVIIFVTYLSRGLTEYSEKPANQKVQYFAGWLVILILLEIYFGALVAGLHAGKVYNTWPLMDGQIIPDGLLLHNPVWLNLFENPLMVQFIHRFFAYFLFVTAVIHALYVQKKVPHSTHSRRAFFMCIMIAVQALLGIVTLLHEVPISLGLIHQSIALAILCFSVAHWRATKGAYRTVE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AILU01000004
EMBL· GenBank· DDBJ
EJF81234.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp