I7D0G4 · I7D0G4_NATSJ

Function

function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.
One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site119(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site123-125(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site227Plays an important role in substrate specificity
Binding site242(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site353-355(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncobalt ion binding
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionmethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Molecular Functionserine binding
Molecular Functionzinc ion binding
Biological Processfolic acid metabolic process
Biological Processglycine biosynthetic process from serine
Biological ProcessL-serine catabolic process
Biological Processmethylation
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      glyA
    • Ordered locus names
      NJ7G_3408

Organism names

  • Taxonomic identifier
  • Strain
    • J7-2
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Natrialbaceae > Natrinema

Accessions

  • Primary accession
    I7D0G4

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue228N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain7-384Serine hydroxymethyltransferase-like
Region345-368Disordered

Sequence similarities

Belongs to the SHMT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    417
  • Mass (Da)
    44,552
  • Last updated
    2012-10-03 v1
  • Checksum
    B63238EF8371C779
MNHDQVRDVDPAVADALEGEVDRQRETLQMIASENHASEAVIDAQGSALTNKYAEGYPGERYYGGCEYADTVEELAIERATELFGADHVNVQPHSGTQANQSVYFAMLEPGDKILSLDLNHGGHLSHGHPANFTGQLYEVEQYEVDPETGYIDYDALADHAAEFDPDIIVSGYSAYPREIEWERIQAAADEVDALHLADIAHITGLVAAGVHPSPVGVADFVTGSTHKTIRAGRGGIVMCDEAYADDIDSAVFPGGQGGPLMHNVAGKAVGFKEAIEPAFTEYAEQTVANAQALGDSLSENGFSLVSDGTDNHLVLVDLRDSHPDTSGSDAEAALEEAGIVLNGNTVPGETRSPFNPSGIRAGTPALTTRGFDEDDCRKVGDLIARVVDAPEDEAVIEAVRDEVTTLCDENPLYEDE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP003412
EMBL· GenBank· DDBJ
AFO58626.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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