I6TF46 · I6TF46_9NEOP
- ProteinNADH-ubiquinone oxidoreductase chain 5
- GeneND5
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids582 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Catalytic activity
- a ubiquinone + 5 H+(in) + NADH = a ubiquinol + 4 H+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex I | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Molecular Function | NADH dehydrogenase activity | |
Biological Process | ATP synthesis coupled electron transport | |
Biological Process | electron transport coupled proton transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 5
- EC number
- Alternative names
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Lepidoptera > Glossata > Ditrysia > Bombycoidea > Saturniidae > Saturniinae > Saturniini > Actias
Accessions
- Primary accessionI6TF46
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 7-32 | Helical | ||||
Sequence: SICYISFFFLFMYSMFNFMLMIYFIM | ||||||
Transmembrane | 62-79 | Helical | ||||
Sequence: LLFMMFVCLISSVVIYYS | ||||||
Transmembrane | 91-108 | Helical | ||||
Sequence: RFIILVLLFVFSMILLII | ||||||
Transmembrane | 154-174 | Helical | ||||
Sequence: VFILMVISWMLNYGSWDYISY | ||||||
Transmembrane | 186-204 | Helical | ||||
Sequence: VIGVMIILAAMTKSAQIPF | ||||||
Transmembrane | 210-234 | Helical | ||||
Sequence: AAMAAPTPVSALVHSSTLVTVGVYL | ||||||
Transmembrane | 246-264 | Helical | ||||
Sequence: FFFKILLMLSILTMFMAGI | ||||||
Transmembrane | 307-324 | Helical | ||||
Sequence: AMFKALLFMCAGVIIHMM | ||||||
Transmembrane | 336-361 | Helical | ||||
Sequence: VSIYIPLTSLCLNISNMALCGIPFLA | ||||||
Transmembrane | 368-388 | Helical | ||||
Sequence: LVLEMVSLSSLNFLVFFFYYI | ||||||
Transmembrane | 400-418 | Helical | ||||
Sequence: LLMYTMVMDFNLMVIYNLY | ||||||
Transmembrane | 430-451 | Helical | ||||
Sequence: VLLFMSVISGSMLSWLIFSYPY | ||||||
Transmembrane | 457-477 | Helical | ||||
Sequence: FNMKMMVIYVSLIGGILGYLV | ||||||
Transmembrane | 497-517 | Helical | ||||
Sequence: FFCLMWFMPNLSTYGVTYYFL | ||||||
Transmembrane | 561-581 | Helical | ||||
Sequence: IYLFSFVLWLFIMLMMITMII |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 109-386 | NADH:quinone oxidoreductase/Mrp antiporter membrane subunit | ||||
Sequence: SPNMVSILLGWDGLGLVSYCSVIYYQNLKSYNAGMLTALTNRIGDVFILMVISWMLNYGSWDYISYLEFMKNDFMMEVIGVMIILAAMTKSAQIPFSSWLPAAMAAPTPVSALVHSSTLVTVGVYLLNRFNMLLIDMFFFKILLMLSILTMFMAGISANHEFDLKKIIALSTLSQLGLMMSILSMGFPNLAFFHLLTHAMFKALLFMCAGVIIHMMNDIQDIRYMGGVSIYIPLTSLCLNISNMALCGIPFLAGFYSKDLVLEMVSLSSLNFLVFFFY | ||||||
Domain | 396-577 | NADH dehydrogenase subunit 5 C-terminal | ||||
Sequence: YTFRLLMYTMVMDFNLMVIYNLYDEDFIMLKSMMVLLFMSVISGSMLSWLIFSYPYMIYLPFNMKMMVIYVSLIGGILGYLVSNMKVYSVNKFLMTYSLSNFFCLMWFMPNLSTYGVTYYFLNLGQNLMKNIDLGWSELYSGQGMVNILKNNSIFYNIFQSNNMKIYLFSFVLWLFIMLMMI |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length582
- Mass (Da)67,667
- Last updated2012-10-03 v1
- Checksum9BA80AF95CC0F731
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JX186589 EMBL· GenBank· DDBJ | AFM95199.1 EMBL· GenBank· DDBJ | Genomic DNA |