I3YC34 · I3YC34_THIV6

Function

function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.

Features

Showing features for binding site.

166950100150200250300350400450500550600650
TypeIDPosition(s)Description
Binding site40-47ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentexcinuclease repair complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionDNA binding
Molecular Functionexcinuclease ABC activity
Biological Processnucleotide-excision repair
Biological ProcessSOS response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    UvrABC system protein B
  • Short names
    Protein UvrB
  • Alternative names
    • Excinuclease ABC subunit B

Gene names

    • Name
      uvrB
    • Ordered locus names
      Thivi_2618

Organism names

Accessions

  • Primary accession
    I3YC34

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, motif.

TypeIDPosition(s)Description
Domain27-160Helicase ATP-binding
Motif93-116Beta-hairpin
Domain431-584Helicase C-terminal
Domain630-665UVR

Domain

The beta-hairpin motif is involved in DNA binding.

Sequence similarities

Belongs to the UvrB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    669
  • Mass (Da)
    75,233
  • Last updated
    2012-09-05 v1
  • Checksum
    E313ED0A3B2ED10D
MSHSSFQLVAKFAPAGDQPAAIRQLVAGLNDGEAGMTLLGVTGSGKTFTIANVIERIQRPALVLAPNKTLAAQLYSEMRDFFPNNAVEYFVSYYDYYQPEAYVPATDTYIEKDASINEHIEQMRLSATKALLERKDVIIVATVSSIYGLGDPEAYLKMVLILKRGDRIDQRAILRRLADLQYKRNEVELARGTYRVRGDVIDIHPAESDEEAIRIELFDEEIEALSLFDPLTGEVRRKVTRYTVFPKTHYATPRATILNAVEQIKPELKQRLDWLRDNQKLVEAQRLEQRTLYDLEMMLEVGYCSGIENYSRYLSGRGPGEAPPTLYDYLPPDAIVVIDESHVTIPQLGGMYRGDRSRKENLVEYGFRLPSALDNRPLKFEEFQARQPQTIYVSATPRQYEIDHSGAVVEQVVRPTGLVDPELEVRPALNQVDDLLSEIGPRVAVDERVLVTTLTKRMAEDLTDYLNDHGVKVRYLHSDIETVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSADSLIQTIGRAARNAHGKAILYADKITGSMQRAIEETDRRRAKQVASNLASGVTPQTIRKAVADILESATPGAPMKARAFAKVAEQVAEYARLTPAQMAKRLKSLEKEMYQHAKNLEFEQAAAIRDQIRELQQAGIAA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP003154
EMBL· GenBank· DDBJ
AFL74552.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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