I2H7L8 · I2H7L8_HENB6
- ProteinOctanoyltransferase
- GeneTBLA0H00810
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids336 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
Catalytic activity
- L-lysyl-[protein] + octanoyl-[ACP] = H+ + holo-[ACP] + N6-octanoyl-L-lysyl-[protein]
Pathway
Protein modification; protein lipoylation via endogenous pathway; protein N6-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.
Features
Showing features for site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 237 | Lowers pKa of active site Cys | ||||
Sequence: K | ||||||
Active site | 271 | Acyl-thioester intermediate | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | lipoyl(octanoyl) transferase activity |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOctanoyltransferase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Henningerozyma
Accessions
- Primary accessionI2H7L8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 107-312 | BPL/LPL catalytic | ||||
Sequence: MKPNPIVLTFEFEPTFTGGKRIKKTITKEQIERFETFTTSGNHIKPKFVLVERGGQITFHGPGQMVAYVILDLQSFKNLRARDLVCILEKSMVRGLSMLKNNQDDSAALSLLTESRTGSETGIWIKNTNKKIGSLGINVRRSVTSHGVCINVEPDLAYLNNFRKCSGLPNCEATSINDQLPGSNINVQDMAIAFTKELAKHLGIER |
Sequence similarities
Belongs to the LipB family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length336
- Mass (Da)38,311
- Last updated2012-07-11 v1
- Checksum5EA437735BEC2F61
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HE806323 EMBL· GenBank· DDBJ | CCH62370.1 EMBL· GenBank· DDBJ | Genomic DNA |