I2FQ94 · I2FQ94_USTHO

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Probably binds two magnesium or manganese ions per subunit.

Features

Showing features for binding site, active site, site.

136250100150200250300350
TypeIDPosition(s)Description
Binding site104Mg2+ 1 (UniProtKB | ChEBI)
Binding site132Mg2+ 1 (UniProtKB | ChEBI)
Active site205
Active site244Proton donor/acceptor
Binding site244Mg2+ 1 (UniProtKB | ChEBI)
Binding site246Mg2+ 1 (UniProtKB | ChEBI)
Site246Transition state stabilizer
Site324Important for catalytic activity
Binding site350Mg2+ 1 (UniProtKB | ChEBI)
Active site351Proton acceptor
Binding site351Mg2+ 1 (UniProtKB | ChEBI)
Site351Interaction with DNA substrate

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular Functionnuclease activity
Biological ProcessDNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA-(apurinic or apyrimidinic site) endonuclease
  • EC number

Gene names

    • ORF names
      UHOR_08713

Organism names

Accessions

  • Primary accession
    I2FQ94

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-23Polar residues
Region1-92Disordered
Domain114-351Endonuclease/exonuclease/phosphatase

Sequence similarities

Belongs to the DNA repair enzymes AP/ExoA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    362
  • Mass (Da)
    39,736
  • Last updated
    2012-07-11 v1
  • Checksum
    D329B4ACCE96D3A0
MATRRSSSRTATFAASQEVAKVASASPSPAKPKRKATDSASSVAQKNGARKSRKKAVADSDSPSAPKSEDTTADPSLPKNIKMPATLSYPRPTSPGAVRVTCWNITSLKSSEPKGMMRYIEAEDADIIVLSETKVNDVPMHPGLTKIYKHQYWGIGKKKGYTGLAILSKIEPIKAVYGLPGLKYQDTKGRIVTLEFENTFLVGTYAVNAGEGLKTMATKQAWNTAFATYLAWLDSKKPVIWCGDFNVVQDERDLAGASKKWNKTPGYTAIECDAHRELIQGTATPTSKPLVDVWRQKHPDAVGHYTFYGWRGFCRAKGIGWRLDSFILSERIASKALECEIRHECFGASDHVPIYCDIQGPL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-23Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAGI01000140
EMBL· GenBank· DDBJ
CCF49087.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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