H8WGT9 · H8WGT9_ECTFE

Function

function

GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man5GlcNAc2-PP-dolichol core oligosaccharide. Man5GlcNAc2-PP-dolichol is a substrate for ALG3, the following enzyme in the biosynthetic pathway.

Catalytic activity

Pathway

Protein modification; protein glycosylation.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular FunctionGDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity
Biological Processprotein N-linked glycosylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
  • EC number
  • Alternative names
    • Asparagine-linked glycosylation protein 11 homolog

Gene names

    • Name
      alg11

Organism names

Accessions

  • Primary accession
    H8WGT9

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass membrane protein

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-190ALG11 mannosyltransferase N-terminal
Domain214-309Glycosyl transferase family 1

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    310
  • Mass (Da)
    35,859
  • Last updated
    2012-05-16 v1
  • Checksum
    8FF508FB69338F17
RVLWNSIQALQRRYSFVQCVVYTGDRGASADEILAKVQQRFGLYLANNVQFVYLRLRCAVEAHRWPRFTLLGQSLGSMLLGLEALLKFCPNVYIDSMGYAFTLPLFRWIGGCKTASYVHYPVVSQDMLEKVSEQVSSFNNPSWISRSKILTKFKIIYYKLFAKIYGFAGRRNDVIMVNSSWTHGHIERIWKPKKVYIVYPPCDTSTFQQLPLDHKSRSLRIISVGQFRPEKDHKMQIRVLQRLLTALSRKQRQGVMLVLVGSCRNSEDQARVEELKQYAKQLGVGDRVLFRINVSYQELQDELCQASVAI

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue310

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HE591452
EMBL· GenBank· DDBJ
CCD41823.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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