G9CTS8 · G9CTS8_TAPPI

Function

function

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular Functionmelanocyte-stimulating hormone receptor activity
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Processregulation of metabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Melanocyte-stimulating hormone receptor
  • Short names
    MSH-R
  • Alternative names
    • Melanocortin receptor 1

Gene names

    • Name
      MC1R

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Tapiridae > Tapirus

Accessions

  • Primary accession
    G9CTS8

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane16-35Helical
Transmembrane47-71Helical
Transmembrane91-112Helical
Transmembrane133-153Helical
Transmembrane159-186Helical
Transmembrane207-234Helical
Transmembrane254-272Helical

Keywords

Interaction

Subunit

Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Interacts with OPN3; the interaction results in a decrease in MC1R-mediated cAMP signaling and ultimately a decrease in melanin production in melanocytes.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain27-270G-protein coupled receptors family 1 profile

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Fragment
  • Length
    277
  • Mass (Da)
    30,753
  • Last updated
    2012-02-22 v1
  • Checksum
    B65A8E8B5DDE1A0B
NQTGHWCMEVLIPDGLFLSLGLVSLVENVLVVAAITKNRNLHSPMYYFICCLAVSDLLVSVSNVLDTAILLLLEAGTLAIRASVVQQLDDVIDVLICGSMVSSLCFLGAIAVDRYISIFYALRYHSIVTLPRAWHAITAIWVASVLSSTLFIAYYNHTAVLLCLVSFFVAMLALMAVLYLHMLARACQHARGIARLHKRQHPVHQSFGLKGAATLTILMGIFFLCWGPFFLHLLLILLCPQHPTCGCVFKNFKLFLTLIICNAIIDPLIYAFRSQEL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue277

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JF718946
EMBL· GenBank· DDBJ
AEU10915.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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