G4CST3 · G4CST3_9NEIS

Function

function

Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site49-53GTP (UniProtKB | ChEBI)
Binding site54Zn2+ (UniProtKB | ChEBI); catalytic
Binding site65Zn2+ (UniProtKB | ChEBI); catalytic
Binding site67Zn2+ (UniProtKB | ChEBI); catalytic
Binding site70GTP (UniProtKB | ChEBI)
Binding site92-94GTP (UniProtKB | ChEBI)
Binding site114GTP (UniProtKB | ChEBI)
Active site126Proton acceptor
Active site128Nucleophile
Binding site149GTP (UniProtKB | ChEBI)
Binding site154GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionGTP binding
Molecular FunctionGTP cyclohydrolase II activity
Molecular Functionzinc ion binding
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GTP cyclohydrolase-2
  • EC number
  • Alternative names
    • GTP cyclohydrolase II

Gene names

    • Name
      ribA
    • ORF names
      HMPREF9370_2074

Organism names

  • Taxonomic identifier
  • Strain
    • 9715
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria

Accessions

  • Primary accession
    G4CST3

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-170GTP cyclohydrolase II

Sequence similarities

Belongs to the GTP cyclohydrolase II family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    194
  • Mass (Da)
    21,173
  • Last updated
    2011-12-14 v1
  • Checksum
    7D2D67AA2F72B52F
MQGLKFVASCRLPTEWGVFMMHGFEEAGGQEHVALVMGDLGDGEAVLSRVHSECLTGDALFSQKCDCGPQLQAAMQAVQQEGRGVIAYLRQEGRGIGLINKIRAYQLQDQGMDTVEANVALGLPVDARDFTLARDIFRHLGVKSIRLLTNNPQKVAVLENAGIRVVERVPLRVGENAENELYLSTKAGKLGHFL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGAZ01000070
EMBL· GenBank· DDBJ
EGZ44548.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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