G4CST3 · G4CST3_9NEIS
- ProteinGTP cyclohydrolase-2
- GeneribA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids194 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
Catalytic activity
- GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H+ + 2 phosphate
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 49-53 | GTP (UniProtKB | ChEBI) | ||||
Sequence: RVHSE | ||||||
Binding site | 54 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: C | ||||||
Binding site | 65 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: C | ||||||
Binding site | 67 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: C | ||||||
Binding site | 70 | GTP (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 92-94 | GTP (UniProtKB | ChEBI) | ||||
Sequence: EGR | ||||||
Binding site | 114 | GTP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Active site | 126 | Proton acceptor | ||||
Sequence: D | ||||||
Active site | 128 | Nucleophile | ||||
Sequence: R | ||||||
Binding site | 149 | GTP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 154 | GTP (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | GTP binding | |
Molecular Function | GTP cyclohydrolase II activity | |
Molecular Function | zinc ion binding | |
Biological Process | riboflavin biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGTP cyclohydrolase-2
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria
Accessions
- Primary accessionG4CST3
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 8-170 | GTP cyclohydrolase II | ||||
Sequence: ASCRLPTEWGVFMMHGFEEAGGQEHVALVMGDLGDGEAVLSRVHSECLTGDALFSQKCDCGPQLQAAMQAVQQEGRGVIAYLRQEGRGIGLINKIRAYQLQDQGMDTVEANVALGLPVDARDFTLARDIFRHLGVKSIRLLTNNPQKVAVLENAGIRVVERVP |
Sequence similarities
Belongs to the GTP cyclohydrolase II family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length194
- Mass (Da)21,173
- Last updated2011-12-14 v1
- Checksum7D2D67AA2F72B52F
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AGAZ01000070 EMBL· GenBank· DDBJ | EGZ44548.1 EMBL· GenBank· DDBJ | Genomic DNA |