F9ZRB8 · F9ZRB8_ACICS

Function

function

Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

Catalytic activity

Features

Showing features for binding site.

124120406080100120140160180200220240
TypeIDPosition(s)Description
Binding site87phosphate (UniProtKB | ChEBI); substrate
Binding site125-127phosphate (UniProtKB | ChEBI); substrate

GO annotations

AspectTerm
Molecular Function3'-5'-RNA exonuclease activity
Molecular FunctiontRNA binding
Molecular FunctiontRNA nucleotidyltransferase activity
Biological ProcessrRNA catabolic process
Biological ProcessrRNA processing
Biological ProcesstRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonuclease PH
  • EC number
  • Short names
    RNase PH
  • Alternative names
    • tRNA nucleotidyltransferase

Gene names

    • Name
      rph
    • Ordered locus names
      Atc_2268

Organism names

Accessions

  • Primary accession
    F9ZRB8

Proteomes

Interaction

Subunit

Homohexameric ring arranged as a trimer of dimers.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-141Exoribonuclease phosphorolytic
Domain160-224Exoribonuclease phosphorolytic

Sequence similarities

Belongs to the RNase PH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    241
  • Mass (Da)
    26,365
  • Last updated
    2011-10-19 v1
  • Checksum
    A760F803B365FB90
MPRPSGRDAQTLRPVEIIRPFTKYAEGSVLIACGDTRVLCTASIEDKVPPFLKGQGRGWVTAEYGMLPRSTQERMPREAAKGKIGGRTHEIQRLIGRSLRAAVDLEALGERTVWIDCDVLQADGGTRTASITGACIALADALQGLLQRGVLTHNPWRHWVAAVSVGIREDEAILDLDYAEDSTAEVDMNVVMTDDGRFVEVQGTAEGAAFSAAQMADMLLLARRGIDRLIARQKSEFPHWP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002573
EMBL· GenBank· DDBJ
AEK58916.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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