F8DYN2 · F8DYN2_CORRG

Function

function

Catalyzes the conversion of lactate to pyruvate.

Catalytic activity

Activity regulation

Allosterically activated by fructose 1,6-bisphosphate (FBP).

Pathway

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

Features

Showing features for binding site, active site.

132250100150200250300
TypeIDPosition(s)Description
Binding site13-18NAD+ (UniProtKB | ChEBI)
Binding site17NAD+ (UniProtKB | ChEBI)
Binding site38NAD+ (UniProtKB | ChEBI)
Binding site43NAD+ (UniProtKB | ChEBI)
Binding site69NAD+ (UniProtKB | ChEBI)
Binding site83-84NAD+ (UniProtKB | ChEBI)
Binding site86substrate
Binding site92substrate
Binding site99NAD+ (UniProtKB | ChEBI)
Binding site105NAD+ (UniProtKB | ChEBI)
Binding site122-124NAD+ (UniProtKB | ChEBI)
Binding site124-127substrate
Binding site147NAD+ (UniProtKB | ChEBI)
Binding site152-155substrate
Binding site157beta-D-fructose 1,6-bisphosphate (UniProtKB | ChEBI); allosteric activator
Binding site172beta-D-fructose 1,6-bisphosphate (UniProtKB | ChEBI); allosteric activator
Active site179Proton acceptor
Binding site233substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionL-lactate dehydrogenase activity
Biological Processglycolytic process
Biological Processlactate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    L-lactate dehydrogenase
  • EC number
  • Short names
    L-LDH

Gene names

    • Name
      ldh
    • Ordered locus names
      CRES_0511

Organism names

Accessions

  • Primary accession
    F8DYN2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue224Phosphotyrosine

Keywords

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-146Lactate/malate dehydrogenase N-terminal
Domain149-312Lactate/malate dehydrogenase C-terminal

Sequence similarities

Belongs to the LDH/MDH superfamily. LDH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    322
  • Mass (Da)
    34,678
  • Last updated
    2011-09-21 v1
  • Checksum
    FCBB037878192ADE
MELTSGTKIVLIGAGDVGIAYAYTIVNQGLTDHLAIIDIDERKTWGHVQDLNHAVPWSGHNTRVTVGTYEDCRDAAIVVNCAGVAQKPGETRLDLVARNTDIFRSIVGNVMEHGFNGVFIVATNPVDILSYATWKFSGLPSSRIIGSGTILDTARYRHALGEYFQVADTSVHAYVIGEHGDTELPVLSAGSVAGVGLAKRLAQVSERGSEDAEEIFERTRTAAYEIIKAKGSTSFGIGMGLARITRAVLQNQDVVLPVSALLEGEYGRDDVYIGTPAVINRSGIRHVVELDLNEDEAQKFDHSVSVLREVMGEAGLLEVASE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002857
EMBL· GenBank· DDBJ
AEI08874.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp