F5HN75 · CPAR_ASPOZ

Function

function

Transcription factor; part of the gene cluster that mediates the biosynthesis of the fungal neurotoxin cyclopiazonic acid (CPA), a nanomolar inhibitor of Ca2+-ATPase with a unique pentacyclic indole tetramic acid scaffold.

Features

Showing features for dna binding.

159850100150200250300350400450500550
TypeIDPosition(s)Description
DNA binding22-51Zn2-C6 fungal-type

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionzinc ion binding
Biological ProcessDNA-templated transcription

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transcription factor cpaR
  • Alternative names
    • Cyclopiazonic acid biosynthesis cluster protein R

Gene names

    • Name
      cpaR

Organism names

  • Taxonomic identifier
  • Strain
    • NBRC 4177
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati

Accessions

  • Primary accession
    F5HN75

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Has no significant effect on the synthesis of 2-oxocyclopiazonic acid, cyclopiazonic acid (CPA) and their biosynthetic intermediates.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004453891-598Transcription factor cpaR

Structure

Family & Domains

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    598
  • Mass (Da)
    67,672
  • Last updated
    2011-07-27 v1
  • Checksum
    995B871B57140B4C
MPETHQNTLTWKGTRLPAGEACNGCRERKRRCVRRKRELPCLSCQAENRPCDVSRYRRRRRRRRGPNKRNCKSLRVLGGQSAEPFNMHQQPDTDSCSEIQHGIETDECGSQCRIPSQSPGPYPEPQPAASTYSLCLPSYVTGVPKHLALVTLNALREKGAFTLPPAEIQTYLISSYIMHVHPDMPFLDLERLLEAVILRCRGRQTSMLLLQAVMFAGSIFLDPVYLHLMGYTSRRAAMRDLFGRAKLLYECGFEVQPTYKLQSLLLFTLFHEDDLAGSSFWMGEAWNLAKTIGLQYDLQEVPVDESSSELAFRRRLWWCVYTRDRLLALSTRSAMHISDGDYNVPMLALADFKSCFGTAEAYRALQLDSDLRTDGTKTALALTFIYKTKLSQLIGRVLMSQYTIGSASPTTMLYYPRPTPISLSDFLGMENDLDVWETSLPSLLEFPLPLLSPVSQAEKIIYAQRAMLHMIYLTCINALHRPWSSSAQPTSSDPWEGAFRDLSAWKIEYASQAILMIATHLHSIGLTNFLADTAVPSLLSAMITHIVRLNSDILVAPEANAVCFVQGWECLQGLREKYEWARHAAAFIRFTTRSLRTG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB506492
EMBL· GenBank· DDBJ
BAK26563.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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