F1ANB3 · F1ANB3_ANOQU

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    F1ANB3

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane40-61Helical
Transmembrane124-149Helical
Transmembrane161-188Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-213Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    213
  • Mass (Da)
    22,679
  • Last updated
    2011-05-03 v1
  • Checksum
    4C9CEBE69B26F0CD
GAWAGMVGTSLSILIRAELGHPGAFIGDDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWMLPPSLTLLISSSMVENGAGTGWTVYPPLSSGIAHAGASVDLAIFSLHLAGISSILGAVNFITTVINMRAPGITLDRMPLFVWSVVITAVLLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue213

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GU908030
EMBL· GenBank· DDBJ
ADE27514.1
EMBL· GenBank· DDBJ
Genomic DNA
GU908031
EMBL· GenBank· DDBJ
ADE27515.1
EMBL· GenBank· DDBJ
Genomic DNA
GU908032
EMBL· GenBank· DDBJ
ADE27516.1
EMBL· GenBank· DDBJ
Genomic DNA
GU908033
EMBL· GenBank· DDBJ
ADE27517.1
EMBL· GenBank· DDBJ
Genomic DNA
GU908034
EMBL· GenBank· DDBJ
ADE27518.1
EMBL· GenBank· DDBJ
Genomic DNA
GU908035
EMBL· GenBank· DDBJ
ADE27519.1
EMBL· GenBank· DDBJ
Genomic DNA
GU908036
EMBL· GenBank· DDBJ
ADE27520.1
EMBL· GenBank· DDBJ
Genomic DNA
GU908037
EMBL· GenBank· DDBJ
ADE27521.1
EMBL· GenBank· DDBJ
Genomic DNA
GU908038
EMBL· GenBank· DDBJ
ADE27522.1
EMBL· GenBank· DDBJ
Genomic DNA
GU908039
EMBL· GenBank· DDBJ
ADE27523.1
EMBL· GenBank· DDBJ
Genomic DNA
GU908040
EMBL· GenBank· DDBJ
ADE27524.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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