E3QER5 · VPS10_COLGM

Function

function

Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentGolgi apparatus
Cellular Componentmembrane
Biological Processprotein transport
Biological Processvacuolar transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Vacuolar protein sorting/targeting protein 10
  • Alternative names
    • Carboxypeptidase Y receptor (CPY receptor)
    • Sortilin VPS10
    • Vacuolar carboxypeptidase sorting receptor VPS10

Gene names

    • Name
      VPS10
    • ORF names
      GLRG_04515

Organism names

Accessions

  • Primary accession
    E3QER5

Proteomes

Organism-specific databases

Subcellular Location

Golgi apparatus, trans-Golgi network membrane
; Multi-pass membrane protein
Prevacuolar compartment membrane
; Multi-pass membrane protein
Note: Cycles between the Golgi apparatus and the prevacuolar compartment.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain27-1385Lumenal
Transmembrane1386-1406Helical
Topological domain1407-1435Cytoplasmic
Transmembrane1436-1456Helical
Topological domain1457-1518Lumenal

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-26
ChainPRO_000040751527-1518Vacuolar protein sorting/targeting protein 10
Glycosylation307N-linked (GlcNAc...) asparagine
Glycosylation332N-linked (GlcNAc...) asparagine
Glycosylation1001N-linked (GlcNAc...) asparagine
Glycosylation1293N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for repeat, region.

TypeIDPosition(s)Description
Repeat64-74BNR 1
Repeat107-118BNR 2
Repeat453-464BNR 3
Repeat496-506BNR 4
Region657-681Disordered
Repeat751-761BNR 5
Repeat848-857BNR 6
Repeat1132-1142BNR 7
Repeat1179-1188BNR 8

Sequence similarities

Belongs to the VPS10-related sortilin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    1,518
  • Mass (Da)
    170,158
  • Last updated
    2011-01-11 v1
  • Checksum
    919A6A53E2E11998
MRLRGKTVASWRILLSVLTLAAAVQAKDEPTIKVTTIKHPPLNLNYFEDSNTVLYQDISERNLYRSEDAGITWDRVKDIPDNQASLLTMHSFDKNRAYVLTQGTEHFKTTDRGKSWQKFSSGAPPNIFMGGDILHFHAGDPDRVIFNGADCIGIFCDLITLYTTDNFKSKAKFLRGNTEGCYWAKSSDLFTTGKDDLDKQRILCVVRDNFSPFKEDNRLLASDNYFQKVDNKVQEFEPDMDTNHGVQGVVSLAVVKKYLMVATSSLNTDEMGLFVTDDTIKWHRAMFPTSHGHKVNQGAYTVLESTNYSIQIDVMNTRPSNPTGVMFTSNSNGTFFTENLEHTNRNTNGHVDFEKITGVQGIFMVNVVQNWEEVEKDTNRGGKHVQKEIVSKITFDDGRTFHDLKSGGDQLHLHSVTDLDNVGRVFSSPAPGLVLAIGNKGKSLGKFGDGDVYVSDDAGVTWKKALDGPHKYEFGDLGSILVAVKDSHKEDIGEIRYSLDHGESWKTAPLPDDLKIKPELLTTTQDSTSLKFLLVGKTGGDNPKFHIIALDFEGLHERTCKEDDFEDWHARLDENGKPSCLMGHKQTYRRRKKTADCFLNQEFKDPVPVTEDCECTDADFECDYNFIRDGDNCKKAGPIIAPDNVCKNARPDDTFKGSSGWRKIPGNTCKRKSGDQKDDPVERKCSEAVNAPAAPADGKIKAVQHVFKTDFKDFEKIYLERGESSTEVDETIIVRPVEYSGNSMRADNQIWRTKDHGKNWERILQDEDVRGIYPHSFFKDVVFFTTDSKKVLYTIDRAEHFHSFEAPTKPGSGNPLSFHPDKKDWLIWVGEKCEKVNGKETCFTEASISRDRGDNWKTAMRYVQKCEFTGHSAYRYRDLRQIVCLAHKEENNEKDNPKVIVSSNDFFDEDKTFHQDRVKNFALMAEFIVVAAEDQEKQGLRALASLDGVSYAEAHFPVNFKVSHQNAYTVLDSSTHAVNLFVATETAEGRRYGSIIKSNSNGTSYVMSAQAVNCNDQYYVDFEKIPGLEGVALINTVANRDKRNEPKKVQTQISHNDGSQWAFLPPPKADVDGKSYSCSSTEGDEKCALHLHHYTERSDKRKTFSAATAVGLMFGNGNVGSSLSSLKEADTFMTTDAGITWKNVKKGAWTWQYGDQGSIVVLVQRASRENPVKTKMISYTTDEGKTWKDFAFTDKEVTVLDISTLRSGASRNFLIWCKDDGGETFSVNVDFTGLADRPCKSDEGSSDYYLWSPKHPSQPDNCLFGHVSQYLRKKDDANCYNDARVQHLYQVENCTCTRADYECDYNYELGTDKQCKLVPGTSPISAEQWCKENPDAVEYYEPTGFRRIPLTTCIGNGHNELDKQSKAHPCAGKEDEFERRRRTSGIAIFFAVVIPFGLAGAIGWWVYRNWNGKIGQIRLGESSSLDNDAPWVKYPVIALSAVVAVAAALPLVASALWRRATSAYESVSGGGGGGGSWLSGRGNRRFTTRDSFARGRGDYAVVDDDEGELLGDDSDEEV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GG697344
EMBL· GenBank· DDBJ
EFQ29371.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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