E3QER5 · VPS10_COLGM
- ProteinVacuolar protein sorting/targeting protein 10
- GeneVPS10
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1518 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | Golgi apparatus | |
Cellular Component | membrane | |
Biological Process | protein transport | |
Biological Process | vacuolar transport |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameVacuolar protein sorting/targeting protein 10
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Glomerellales > Glomerellaceae > Colletotrichum > Colletotrichum graminicola species complex
Accessions
- Primary accessionE3QER5
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein
Prevacuolar compartment membrane ; Multi-pass membrane protein
Note: Cycles between the Golgi apparatus and the prevacuolar compartment.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 27-1385 | Lumenal | ||||
Sequence: KDEPTIKVTTIKHPPLNLNYFEDSNTVLYQDISERNLYRSEDAGITWDRVKDIPDNQASLLTMHSFDKNRAYVLTQGTEHFKTTDRGKSWQKFSSGAPPNIFMGGDILHFHAGDPDRVIFNGADCIGIFCDLITLYTTDNFKSKAKFLRGNTEGCYWAKSSDLFTTGKDDLDKQRILCVVRDNFSPFKEDNRLLASDNYFQKVDNKVQEFEPDMDTNHGVQGVVSLAVVKKYLMVATSSLNTDEMGLFVTDDTIKWHRAMFPTSHGHKVNQGAYTVLESTNYSIQIDVMNTRPSNPTGVMFTSNSNGTFFTENLEHTNRNTNGHVDFEKITGVQGIFMVNVVQNWEEVEKDTNRGGKHVQKEIVSKITFDDGRTFHDLKSGGDQLHLHSVTDLDNVGRVFSSPAPGLVLAIGNKGKSLGKFGDGDVYVSDDAGVTWKKALDGPHKYEFGDLGSILVAVKDSHKEDIGEIRYSLDHGESWKTAPLPDDLKIKPELLTTTQDSTSLKFLLVGKTGGDNPKFHIIALDFEGLHERTCKEDDFEDWHARLDENGKPSCLMGHKQTYRRRKKTADCFLNQEFKDPVPVTEDCECTDADFECDYNFIRDGDNCKKAGPIIAPDNVCKNARPDDTFKGSSGWRKIPGNTCKRKSGDQKDDPVERKCSEAVNAPAAPADGKIKAVQHVFKTDFKDFEKIYLERGESSTEVDETIIVRPVEYSGNSMRADNQIWRTKDHGKNWERILQDEDVRGIYPHSFFKDVVFFTTDSKKVLYTIDRAEHFHSFEAPTKPGSGNPLSFHPDKKDWLIWVGEKCEKVNGKETCFTEASISRDRGDNWKTAMRYVQKCEFTGHSAYRYRDLRQIVCLAHKEENNEKDNPKVIVSSNDFFDEDKTFHQDRVKNFALMAEFIVVAAEDQEKQGLRALASLDGVSYAEAHFPVNFKVSHQNAYTVLDSSTHAVNLFVATETAEGRRYGSIIKSNSNGTSYVMSAQAVNCNDQYYVDFEKIPGLEGVALINTVANRDKRNEPKKVQTQISHNDGSQWAFLPPPKADVDGKSYSCSSTEGDEKCALHLHHYTERSDKRKTFSAATAVGLMFGNGNVGSSLSSLKEADTFMTTDAGITWKNVKKGAWTWQYGDQGSIVVLVQRASRENPVKTKMISYTTDEGKTWKDFAFTDKEVTVLDISTLRSGASRNFLIWCKDDGGETFSVNVDFTGLADRPCKSDEGSSDYYLWSPKHPSQPDNCLFGHVSQYLRKKDDANCYNDARVQHLYQVENCTCTRADYECDYNYELGTDKQCKLVPGTSPISAEQWCKENPDAVEYYEPTGFRRIPLTTCIGNGHNELDKQSKAHPCAGKEDEFERRRRTSG | ||||||
Transmembrane | 1386-1406 | Helical | ||||
Sequence: IAIFFAVVIPFGLAGAIGWWV | ||||||
Topological domain | 1407-1435 | Cytoplasmic | ||||
Sequence: YRNWNGKIGQIRLGESSSLDNDAPWVKYP | ||||||
Transmembrane | 1436-1456 | Helical | ||||
Sequence: VIALSAVVAVAAALPLVASAL | ||||||
Topological domain | 1457-1518 | Lumenal | ||||
Sequence: WRRATSAYESVSGGGGGGGSWLSGRGNRRFTTRDSFARGRGDYAVVDDDEGELLGDDSDEEV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-26 | |||||
Sequence: MRLRGKTVASWRILLSVLTLAAAVQA | ||||||
Chain | PRO_0000407515 | 27-1518 | Vacuolar protein sorting/targeting protein 10 | |||
Sequence: KDEPTIKVTTIKHPPLNLNYFEDSNTVLYQDISERNLYRSEDAGITWDRVKDIPDNQASLLTMHSFDKNRAYVLTQGTEHFKTTDRGKSWQKFSSGAPPNIFMGGDILHFHAGDPDRVIFNGADCIGIFCDLITLYTTDNFKSKAKFLRGNTEGCYWAKSSDLFTTGKDDLDKQRILCVVRDNFSPFKEDNRLLASDNYFQKVDNKVQEFEPDMDTNHGVQGVVSLAVVKKYLMVATSSLNTDEMGLFVTDDTIKWHRAMFPTSHGHKVNQGAYTVLESTNYSIQIDVMNTRPSNPTGVMFTSNSNGTFFTENLEHTNRNTNGHVDFEKITGVQGIFMVNVVQNWEEVEKDTNRGGKHVQKEIVSKITFDDGRTFHDLKSGGDQLHLHSVTDLDNVGRVFSSPAPGLVLAIGNKGKSLGKFGDGDVYVSDDAGVTWKKALDGPHKYEFGDLGSILVAVKDSHKEDIGEIRYSLDHGESWKTAPLPDDLKIKPELLTTTQDSTSLKFLLVGKTGGDNPKFHIIALDFEGLHERTCKEDDFEDWHARLDENGKPSCLMGHKQTYRRRKKTADCFLNQEFKDPVPVTEDCECTDADFECDYNFIRDGDNCKKAGPIIAPDNVCKNARPDDTFKGSSGWRKIPGNTCKRKSGDQKDDPVERKCSEAVNAPAAPADGKIKAVQHVFKTDFKDFEKIYLERGESSTEVDETIIVRPVEYSGNSMRADNQIWRTKDHGKNWERILQDEDVRGIYPHSFFKDVVFFTTDSKKVLYTIDRAEHFHSFEAPTKPGSGNPLSFHPDKKDWLIWVGEKCEKVNGKETCFTEASISRDRGDNWKTAMRYVQKCEFTGHSAYRYRDLRQIVCLAHKEENNEKDNPKVIVSSNDFFDEDKTFHQDRVKNFALMAEFIVVAAEDQEKQGLRALASLDGVSYAEAHFPVNFKVSHQNAYTVLDSSTHAVNLFVATETAEGRRYGSIIKSNSNGTSYVMSAQAVNCNDQYYVDFEKIPGLEGVALINTVANRDKRNEPKKVQTQISHNDGSQWAFLPPPKADVDGKSYSCSSTEGDEKCALHLHHYTERSDKRKTFSAATAVGLMFGNGNVGSSLSSLKEADTFMTTDAGITWKNVKKGAWTWQYGDQGSIVVLVQRASRENPVKTKMISYTTDEGKTWKDFAFTDKEVTVLDISTLRSGASRNFLIWCKDDGGETFSVNVDFTGLADRPCKSDEGSSDYYLWSPKHPSQPDNCLFGHVSQYLRKKDDANCYNDARVQHLYQVENCTCTRADYECDYNYELGTDKQCKLVPGTSPISAEQWCKENPDAVEYYEPTGFRRIPLTTCIGNGHNELDKQSKAHPCAGKEDEFERRRRTSGIAIFFAVVIPFGLAGAIGWWVYRNWNGKIGQIRLGESSSLDNDAPWVKYPVIALSAVVAVAAALPLVASALWRRATSAYESVSGGGGGGGSWLSGRGNRRFTTRDSFARGRGDYAVVDDDEGELLGDDSDEEV | ||||||
Glycosylation | 307 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 332 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 1001 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 1293 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for repeat, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 64-74 | BNR 1 | ||||
Sequence: YRSEDAGITWD | ||||||
Repeat | 107-118 | BNR 2 | ||||
Sequence: FKTTDRGKSWQK | ||||||
Repeat | 453-464 | BNR 3 | ||||
Sequence: YVSDDAGVTWKK | ||||||
Repeat | 496-506 | BNR 4 | ||||
Sequence: RYSLDHGESWK | ||||||
Region | 657-681 | Disordered | ||||
Sequence: GSSGWRKIPGNTCKRKSGDQKDDPV | ||||||
Repeat | 751-761 | BNR 5 | ||||
Sequence: WRTKDHGKNWE | ||||||
Repeat | 848-857 | BNR 6 | ||||
Sequence: ISRDRGDNWK | ||||||
Repeat | 1132-1142 | BNR 7 | ||||
Sequence: FMTTDAGITWK | ||||||
Repeat | 1179-1188 | BNR 8 | ||||
Sequence: YTTDEGKTWK |
Sequence similarities
Belongs to the VPS10-related sortilin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length1,518
- Mass (Da)170,158
- Last updated2011-01-11 v1
- Checksum919A6A53E2E11998
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GG697344 EMBL· GenBank· DDBJ | EFQ29371.1 EMBL· GenBank· DDBJ | Genomic DNA |