E3LYX0 · EGG1_CAERE

Function

function

Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial (By similarity).
Seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte (PubMed:16360684).
Conversely, shown to be dispensable for fertilization but required for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane (By similarity).
Appears to recruit or maintain together to the unfertilized oocyte cortex several proteins including chs-1, kinase mbk-2 and pseudophosphatases egg-3, and possibly egg-4 (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Biological Processsingle fertilization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    LDL receptor repeat-containing protein egg-1

Gene names

    • Name
      egg-1
    • ORF names
      CRE_04724

Organism names

Accessions

  • Primary accession
    E3LYX0

Proteomes

Subcellular Location

Cell membrane
; Single-pass type II membrane protein
Note: Localizes to the cell membrane of developing oocytes. Plasma membrane localization requires extracellular matrix protein cbd-1. After fertilization, localizes to endosomes in zygotes.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-49Cytoplasmic
Transmembrane50-70Helical; Signal-anchor for type II membrane protein
Topological domain71-551Extracellular

Keywords

Phenotypes & Variants

Disruption phenotype

RNAi-mediated knockdown results in sterility due to the loss of oocyte fertilization.

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00004427941-551LDL receptor repeat-containing protein egg-1
Glycosylation121N-linked (GlcNAc...) asparagine
Disulfide bond132↔152
Disulfide bond146↔161
Disulfide bond164↔192
Disulfide bond170↔205
Disulfide bond199↔214
Disulfide bond218↔231
Disulfide bond225↔244
Disulfide bond238↔253
Disulfide bond256↔267
Disulfide bond263↔280
Disulfide bond274↔289
Disulfide bond294↔307
Disulfide bond302↔320
Disulfide bond314↔329
Disulfide bond373↔391
Disulfide bond381↔404
Disulfide bond398↔413
Disulfide bond419↔433
Glycosylation423N-linked (GlcNAc...) asparagine
Disulfide bond429↔446
Disulfide bond440↔455
Disulfide bond458↔471
Disulfide bond465↔484
Disulfide bond478↔493
Glycosylation509N-linked (GlcNAc...) asparagine
Glycosylation529N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain124-162LDL-receptor class A 1
Domain163-215LDL-receptor class A 2
Domain217-254LDL-receptor class A 3
Domain255-290LDL-receptor class A 4
Domain293-330LDL-receptor class A 5
Domain372-414LDL-receptor class A 6
Domain418-456LDL-receptor class A 7
Domain457-494LDL-receptor class A 8

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    551
  • Mass (Da)
    59,866
  • Last updated
    2011-01-11 v1
  • Checksum
    574C6A7943B388C8
MSQQPGSDRRVNFAQEEPMTLGEKISHRMDQFKEMVSSGCCSCASRCPSVAIVLILALVILGILAAIPLTLMLTSSAQRMSTDSTDLSPYSIRHPKFWPKTDKIHFNDLDGIPMSSLFPPNVSTCSGFGFACTGAVHMIIPSSKRCDGIKDCQDGSDEENCKECQSVFSCRSHVEEDSKTKRKTKVLPTLICLTAEKLCNDVQDCPDGSDESVCKSTCSKDQFKCTGNNACLPTSAKCDGVNDCTDGSDEKNCNECQKGAHKCGKQCIKASHVCDGVAQCADRSDEKECDCKSCSGSDKALCEDGTCIKRTQVCDGKKDCTDGMDEENCPGSCSIEAFSTKTKQLTCSDEKRYTESEACSGVVEACEQSCPKCHPKLTFTCPAVGGSQKRCIRRSKVCDGINDCDDGADEKNCTPIKECGIENASQFTCDRKCLDASRRCDGVWDCEDKSDEQNCQQCSSGSIRCAADKKCLPAYTRCNGVAECSDGSDEQKCSCEECLGAHSNTYMCNESNRCLKRDEVCSPYSMCPNATYTDKAYCAALVLKNSGRFPY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS268419
EMBL· GenBank· DDBJ
EFO86538.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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