E3LYX0 · EGG1_CAERE
- ProteinLDL receptor repeat-containing protein egg-1
- Geneegg-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids551 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial (By similarity).
Seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte (PubMed:16360684).
Conversely, shown to be dispensable for fertilization but required for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane (By similarity).
Appears to recruit or maintain together to the unfertilized oocyte cortex several proteins including chs-1, kinase mbk-2 and pseudophosphatases egg-3, and possibly egg-4 (By similarity).
Seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte (PubMed:16360684).
Conversely, shown to be dispensable for fertilization but required for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane (By similarity).
Appears to recruit or maintain together to the unfertilized oocyte cortex several proteins including chs-1, kinase mbk-2 and pseudophosphatases egg-3, and possibly egg-4 (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Biological Process | single fertilization |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameLDL receptor repeat-containing protein egg-1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionE3LYX0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type II membrane protein
Note: Localizes to the cell membrane of developing oocytes. Plasma membrane localization requires extracellular matrix protein cbd-1. After fertilization, localizes to endosomes in zygotes.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-49 | Cytoplasmic | ||||
Sequence: MSQQPGSDRRVNFAQEEPMTLGEKISHRMDQFKEMVSSGCCSCASRCPS | ||||||
Transmembrane | 50-70 | Helical; Signal-anchor for type II membrane protein | ||||
Sequence: VAIVLILALVILGILAAIPLT | ||||||
Topological domain | 71-551 | Extracellular | ||||
Sequence: LMLTSSAQRMSTDSTDLSPYSIRHPKFWPKTDKIHFNDLDGIPMSSLFPPNVSTCSGFGFACTGAVHMIIPSSKRCDGIKDCQDGSDEENCKECQSVFSCRSHVEEDSKTKRKTKVLPTLICLTAEKLCNDVQDCPDGSDESVCKSTCSKDQFKCTGNNACLPTSAKCDGVNDCTDGSDEKNCNECQKGAHKCGKQCIKASHVCDGVAQCADRSDEKECDCKSCSGSDKALCEDGTCIKRTQVCDGKKDCTDGMDEENCPGSCSIEAFSTKTKQLTCSDEKRYTESEACSGVVEACEQSCPKCHPKLTFTCPAVGGSQKRCIRRSKVCDGINDCDDGADEKNCTPIKECGIENASQFTCDRKCLDASRRCDGVWDCEDKSDEQNCQQCSSGSIRCAADKKCLPAYTRCNGVAECSDGSDEQKCSCEECLGAHSNTYMCNESNRCLKRDEVCSPYSMCPNATYTDKAYCAALVLKNSGRFPY |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
RNAi-mediated knockdown results in sterility due to the loss of oocyte fertilization.
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000442794 | 1-551 | LDL receptor repeat-containing protein egg-1 | |||
Sequence: MSQQPGSDRRVNFAQEEPMTLGEKISHRMDQFKEMVSSGCCSCASRCPSVAIVLILALVILGILAAIPLTLMLTSSAQRMSTDSTDLSPYSIRHPKFWPKTDKIHFNDLDGIPMSSLFPPNVSTCSGFGFACTGAVHMIIPSSKRCDGIKDCQDGSDEENCKECQSVFSCRSHVEEDSKTKRKTKVLPTLICLTAEKLCNDVQDCPDGSDESVCKSTCSKDQFKCTGNNACLPTSAKCDGVNDCTDGSDEKNCNECQKGAHKCGKQCIKASHVCDGVAQCADRSDEKECDCKSCSGSDKALCEDGTCIKRTQVCDGKKDCTDGMDEENCPGSCSIEAFSTKTKQLTCSDEKRYTESEACSGVVEACEQSCPKCHPKLTFTCPAVGGSQKRCIRRSKVCDGINDCDDGADEKNCTPIKECGIENASQFTCDRKCLDASRRCDGVWDCEDKSDEQNCQQCSSGSIRCAADKKCLPAYTRCNGVAECSDGSDEQKCSCEECLGAHSNTYMCNESNRCLKRDEVCSPYSMCPNATYTDKAYCAALVLKNSGRFPY | ||||||
Glycosylation | 121 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 132↔152 | |||||
Sequence: CTGAVHMIIPSSKRCDGIKDC | ||||||
Disulfide bond | 146↔161 | |||||
Sequence: CDGIKDCQDGSDEENC | ||||||
Disulfide bond | 164↔192 | |||||
Sequence: CQSVFSCRSHVEEDSKTKRKTKVLPTLIC | ||||||
Disulfide bond | 170↔205 | |||||
Sequence: CRSHVEEDSKTKRKTKVLPTLICLTAEKLCNDVQDC | ||||||
Disulfide bond | 199↔214 | |||||
Sequence: CNDVQDCPDGSDESVC | ||||||
Disulfide bond | 218↔231 | |||||
Sequence: CSKDQFKCTGNNAC | ||||||
Disulfide bond | 225↔244 | |||||
Sequence: CTGNNACLPTSAKCDGVNDC | ||||||
Disulfide bond | 238↔253 | |||||
Sequence: CDGVNDCTDGSDEKNC | ||||||
Disulfide bond | 256↔267 | |||||
Sequence: CQKGAHKCGKQC | ||||||
Disulfide bond | 263↔280 | |||||
Sequence: CGKQCIKASHVCDGVAQC | ||||||
Disulfide bond | 274↔289 | |||||
Sequence: CDGVAQCADRSDEKEC | ||||||
Disulfide bond | 294↔307 | |||||
Sequence: CSGSDKALCEDGTC | ||||||
Disulfide bond | 302↔320 | |||||
Sequence: CEDGTCIKRTQVCDGKKDC | ||||||
Disulfide bond | 314↔329 | |||||
Sequence: CDGKKDCTDGMDEENC | ||||||
Disulfide bond | 373↔391 | |||||
Sequence: CHPKLTFTCPAVGGSQKRC | ||||||
Disulfide bond | 381↔404 | |||||
Sequence: CPAVGGSQKRCIRRSKVCDGINDC | ||||||
Disulfide bond | 398↔413 | |||||
Sequence: CDGINDCDDGADEKNC | ||||||
Disulfide bond | 419↔433 | |||||
Sequence: CGIENASQFTCDRKC | ||||||
Glycosylation | 423 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 429↔446 | |||||
Sequence: CDRKCLDASRRCDGVWDC | ||||||
Disulfide bond | 440↔455 | |||||
Sequence: CDGVWDCEDKSDEQNC | ||||||
Disulfide bond | 458↔471 | |||||
Sequence: CSSGSIRCAADKKC | ||||||
Disulfide bond | 465↔484 | |||||
Sequence: CAADKKCLPAYTRCNGVAEC | ||||||
Disulfide bond | 478↔493 | |||||
Sequence: CNGVAECSDGSDEQKC | ||||||
Glycosylation | 509 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 529 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 124-162 | LDL-receptor class A 1 | ||||
Sequence: TCSGFGFACTGAVHMIIPSSKRCDGIKDCQDGSDEENCK | ||||||
Domain | 163-215 | LDL-receptor class A 2 | ||||
Sequence: ECQSVFSCRSHVEEDSKTKRKTKVLPTLICLTAEKLCNDVQDCPDGSDESVCK | ||||||
Domain | 217-254 | LDL-receptor class A 3 | ||||
Sequence: TCSKDQFKCTGNNACLPTSAKCDGVNDCTDGSDEKNCN | ||||||
Domain | 255-290 | LDL-receptor class A 4 | ||||
Sequence: ECQKGAHKCGKQCIKASHVCDGVAQCADRSDEKECD | ||||||
Domain | 293-330 | LDL-receptor class A 5 | ||||
Sequence: SCSGSDKALCEDGTCIKRTQVCDGKKDCTDGMDEENCP | ||||||
Domain | 372-414 | LDL-receptor class A 6 | ||||
Sequence: KCHPKLTFTCPAVGGSQKRCIRRSKVCDGINDCDDGADEKNCT | ||||||
Domain | 418-456 | LDL-receptor class A 7 | ||||
Sequence: ECGIENASQFTCDRKCLDASRRCDGVWDCEDKSDEQNCQ | ||||||
Domain | 457-494 | LDL-receptor class A 8 | ||||
Sequence: QCSSGSIRCAADKKCLPAYTRCNGVAECSDGSDEQKCS |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length551
- Mass (Da)59,866
- Last updated2011-01-11 v1
- Checksum574C6A7943B388C8
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DS268419 EMBL· GenBank· DDBJ | EFO86538.1 EMBL· GenBank· DDBJ | Genomic DNA |