E1V0Q8 · E1V0Q8_MERME

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • 1994
    • 1995
    • 2159
    • 2160
    • 2161
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Zeiogadaria > Gadariae > Gadiformes > Gadoidei > Merlucciidae > Merluccius

Accessions

  • Primary accession
    E1V0Q8

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-35Helical
Transmembrane56-80Helical
Transmembrane100-121Helical
Transmembrane133-151Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-152Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    152
  • Mass (Da)
    16,293
  • Last updated
    2010-11-30 v1
  • Checksum
    D3CC1439E7A66473
GDDQIYNVIVTAHAFVMIFFMVMPLMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLASNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAISQYQTPLFVWSVLITAVLLLLSLP

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue152

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FN688952
EMBL· GenBank· DDBJ
CBL86628.1
EMBL· GenBank· DDBJ
Genomic DNA
FN688999
EMBL· GenBank· DDBJ
CBL86675.1
EMBL· GenBank· DDBJ
Genomic DNA
FN689041
EMBL· GenBank· DDBJ
CBL86717.1
EMBL· GenBank· DDBJ
Genomic DNA
FN689177
EMBL· GenBank· DDBJ
CBL86853.1
EMBL· GenBank· DDBJ
Genomic DNA
FN689178
EMBL· GenBank· DDBJ
CBL86854.1
EMBL· GenBank· DDBJ
Genomic DNA
FN689179
EMBL· GenBank· DDBJ
CBL86855.1
EMBL· GenBank· DDBJ
Genomic DNA
FN689180
EMBL· GenBank· DDBJ
CBL86856.1
EMBL· GenBank· DDBJ
Genomic DNA
FN689181
EMBL· GenBank· DDBJ
CBL86857.1
EMBL· GenBank· DDBJ
Genomic DNA
FN689182
EMBL· GenBank· DDBJ
CBL86858.1
EMBL· GenBank· DDBJ
Genomic DNA
FN689183
EMBL· GenBank· DDBJ
CBL86859.1
EMBL· GenBank· DDBJ
Genomic DNA
FN689184
EMBL· GenBank· DDBJ
CBL86860.1
EMBL· GenBank· DDBJ
Genomic DNA
FN689185
EMBL· GenBank· DDBJ
CBL86861.1
EMBL· GenBank· DDBJ
Genomic DNA
FN689186
EMBL· GenBank· DDBJ
CBL86862.1
EMBL· GenBank· DDBJ
Genomic DNA
FN689187
EMBL· GenBank· DDBJ
CBL86863.1
EMBL· GenBank· DDBJ
Genomic DNA
FN689188
EMBL· GenBank· DDBJ
CBL86864.1
EMBL· GenBank· DDBJ
Genomic DNA
FN689189
EMBL· GenBank· DDBJ
CBL86865.1
EMBL· GenBank· DDBJ
Genomic DNA
FN689190
EMBL· GenBank· DDBJ
CBL86866.1
EMBL· GenBank· DDBJ
Genomic DNA
FN689191
EMBL· GenBank· DDBJ
CBL86867.1
EMBL· GenBank· DDBJ
Genomic DNA
FN689192
EMBL· GenBank· DDBJ
CBL86868.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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