E1ACR3 · NOTR_ASPSM

Function

function

Transcription factor that probably regulates the expression of the gene cluster that mediates the biosynthesis of notoamide, a fungal indole alkaloid that belongs to a family of natural products containing a characteristic bicyclo[2.2.2]diazaoctane core.

Biotechnology

Notoamides have been shown to exhibit antitumoral activities (PubMed:17304611).
Notoamides A-C show moderate cytotoxicity against HeLa and L1210 cells with IC50 values in the range of 22-52 mg/ml, but the IC50 value of notoamide D is greater than 100 mg/ml (PubMed:17304611).
Moreover, notoamide C induces G2/M-cell cycle arrest at a concentration of 6.3 mg/ml (PubMed:17304611).

Features

Showing features for dna binding.

146050100150200250300350400450
TypeIDPosition(s)Description
DNA binding107-126H-T-H motif

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular Functionmethyltransferase activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Notoamide biosynthesis cluster transcriptional coactivator notR
  • Alternative names
    • Notoamide biosynthesis cluster protein R

Organism names

  • Taxonomic identifier
  • Strain
    • MF297-2
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus

Accessions

  • Primary accession
    E1ACR3

Subcellular Location

Keywords

Phenotypes & Variants

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004488211-460Notoamide biosynthesis cluster transcriptional coactivator notR

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain74-145HTH iclR-type
Region300-320Disordered
Compositional bias302-320Polar residues

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    460
  • Mass (Da)
    50,244
  • Last updated
    2010-11-02 v1
  • Checksum
    52237E56FCFE6BD4
MPGIAMDGLSKLEAESERLTATIKSYVRHRRDVESSDQLRASPDANMEASRTKSVILASIANIKALLGGPVELLQDLARQVEIVACLRWLAEYQILACIPAEGGMSIQDLADLAGVPDIQLRRVIRLVGTSGFLQEPMPNYVSHTPLSAQFVTNQSWLDAAVFMAELAAPTALHMPAATHRFGGSRHPTETAYNLALNSLQPFGAAIQERPKLGRQWSAYLHHAVGLHQEKKIADMLSQLKWSSLGNSFVVEVGAQSTSMAHHLANKFPTLHLIVQIDRSRASRLNPDYLWPGEMMNGLTRDFTPQPESSPRPGSASSRVTVTYRSASMPQPVVDAAVYILHVPVLSTNSPAGADAMETVKTELQDYLGILRATAGILLIPTANLLPEPGSLSDPNFEAVARTRDLNYLQLANEGEMEMTDLFSAIETTRDGLGRLVITNQLRSHIGLTVCLTLKHETYC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias302-320Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HM622670
EMBL· GenBank· DDBJ
ADM34151.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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