E0A2M1 · E0A2M1_OVIAM
- ProteinCytochrome c oxidase subunit 1
- GeneCOX1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids514 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2O
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Protein has several cofactor binding sites:
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Ovis
Accessions
- Primary accessionE0A2M1
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 18-37 | Helical | ||||
Sequence: LYLLFGAWAGMVGTALSLLI | ||||||
Transmembrane | 57-83 | Helical | ||||
Sequence: IVTAHAFVMIFFMVMPIMIGGFGNWLV | ||||||
Transmembrane | 104-128 | Helical | ||||
Sequence: LLPPSFLLLLASSMVEAGAGTGWTV | ||||||
Transmembrane | 148-171 | Helical | ||||
Sequence: FSLHLAGVSSILGAINFITTIINM | ||||||
Transmembrane | 183-210 | Helical | ||||
Sequence: LFVWSVLITAVLLLLSLPVLAAGITMLL | ||||||
Transmembrane | 243-261 | Helical | ||||
Sequence: VYILILPGFGMISHIVTYY | ||||||
Transmembrane | 268-291 | Helical | ||||
Sequence: FGYMGMVWAMMSIGFLGFIVWAHH | ||||||
Transmembrane | 303-325 | Helical | ||||
Sequence: AYFTSATMIIAIPTGVKVFSWLA | ||||||
Transmembrane | 337-359 | Helical | ||||
Sequence: AMMWALGFIFLFTVGGLTGIVLA | ||||||
Transmembrane | 379-400 | Helical | ||||
Sequence: YVLSMGAVFAIMGGFVHWFPLF | ||||||
Transmembrane | 412-433 | Helical | ||||
Sequence: IHFAIMFVGVNMTFFPQHFLGL | ||||||
Transmembrane | 453-473 | Helical | ||||
Sequence: ISSMGSFISLTAVMLMIFIIW |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-514 | Cytochrome oxidase subunit I profile | ||||
Sequence: MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMMWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLNDTWAKIHFAIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTMWNTISSMGSFISLTAVMLMIFIIWEAFASKREVLTVDLTTTNLEWLNGCPPPYHTFEEPTYVNLK |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length514
- Mass (Da)57,042
- Last updated2010-10-05 v1
- Checksum1619A9A1546CAC45
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HM236188 EMBL· GenBank· DDBJ | ADI57777.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT781689 EMBL· GenBank· DDBJ | ALN96789.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT768083 EMBL· GenBank· DDBJ | QNN90940.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT768084 EMBL· GenBank· DDBJ | QNN90953.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT768085 EMBL· GenBank· DDBJ | QNN90966.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT768086 EMBL· GenBank· DDBJ | QNN90979.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT768087 EMBL· GenBank· DDBJ | QNN90992.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT768088 EMBL· GenBank· DDBJ | QNN91005.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT768089 EMBL· GenBank· DDBJ | QNN91018.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT768090 EMBL· GenBank· DDBJ | QNN91031.1 EMBL· GenBank· DDBJ | Genomic DNA |