D5U8T3 · D5U8T3_BRAM5

Function

function

Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

FMNH2 (UniProtKB | Rhea| CHEBI:57618 )

Note: Reduced FMN (FMNH2).

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site47NADP+ (UniProtKB | ChEBI)
Binding site53NADP+ (UniProtKB | ChEBI)
Binding site125-127FMN (UniProtKB | ChEBI)
Binding site294FMN (UniProtKB | ChEBI)
Binding site309-313FMN (UniProtKB | ChEBI)
Binding site336FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionchorismate synthase activity
Molecular FunctionFMN binding
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Chorismate synthase
  • EC number
  • Short names
    CS
  • Alternative names
    • 5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

    • Name
      aroC
    • Ordered locus names
      Bmur_1010

Organism names

Accessions

  • Primary accession
    D5U8T3

Proteomes

Subcellular Location

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the chorismate synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    369
  • Mass (Da)
    40,432
  • Last updated
    2010-07-13 v1
  • Checksum
    4C42F443FAF3C636
MGSVFGNNIKLSLFGESHGEAIGCVIDGFPYGINIDYDFVDSEMDRRRAKNAKLATARTESDKPEILSGILENKSTGMPIAAIIKNENKRSGDYSNLKIMPRPSHSDYTAMLRYDGFNDIRGGGHFSGRLTAPLVFAGALAKLALKEKFDIEIAAHIKQIYNIKDKYPNNTFPTYEEFIANYNKELSVFDDEAMNKMINIIEEAKMNMDSVGGIITAAAFNVPAGFGEPFYASIESRIAQSMFAVPAVKGIDFGLGFDFVNYKASECNDLYTIKSYDNIKKVETKTNNNGGILGGISNGMPIIVNAVIKPTPSISKEQLTLNIETKEEDTLIIKGRHDPCIAVRAVPVIEAALAIAILDLCIDMKGKLI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001959
EMBL· GenBank· DDBJ
ADG71106.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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