D4GTA5 · NREA_HALVD
- ProteinDNA repair protein NreA
- GenenreA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids420 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Involved in DNA damage repair. Works together with the UvrABC proteins in repairing DNA damage resulting from exposure to the DNA damaging agent mitomycin C (MMC).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Biological Process | DNA repair |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameDNA repair protein NreA
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Haloferacaceae > Haloferax
Accessions
- Primary accessionD4GTA5
Proteomes
Phenotypes & Variants
Disruption phenotype
Non-essential, but cells lacking this gene are sensitive to DNA damage induced by treatment with MMC. Does not display increased sensitivity to UV light or to the alkylating agent methyl methanesulphonate (MMS).
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 411-420 | Displays increased chromosome fragmentation and delayed recovery relative to wild-type cells. | ||||
Sequence: Missing |
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000442518 | 1-420 | DNA repair protein NreA | |||
Sequence: MRLDEYMDIERDERAERRRLAEEKSYGILDHLETFQDRFEETVQGDSLYGGVSPSIFVGRSNYPNVSTGILSPVGHDEDAASFETSAAWYDEGVSIDDVFQRRTSLLNSNRGTKVTNVADSWDGFLGTQREVAIADRPVTVEIGLDGKPSLDLDASADDVATPVGPRARARSADLAENPHVPKLVKKTLEDDDWNAEGAMTYLYRRGFDVYDINTILSAGALGQTEQRRLVPTRWSITAVDDTLGQYLRGQVKHAESVDGVEIYRNEFIGNAFWVILAPGRWEFELIELKAPGSVWNPDPEAGMYLAADREGYEGRTGYVNETAGAYHASRLGVLEHLQERGRQAKALVIRHVSDDYWGPVGVWQIRESIRHAFEGEMADAETFGDAVRDVTEYLPVSLADLRRKSTMAAGLQTDIFDFA |
Proteomic databases
Interaction
Subunit
Interacts with the DNA polymerase sliding clamp (PCNA) via the PIP (PCNA-interacting peptide) motif.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length420
- Mass (Da)46,864
- Last updated2010-05-18 v1
- Checksum4B84C16C6A9E6A7F
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001956 EMBL· GenBank· DDBJ | ADE03741.1 EMBL· GenBank· DDBJ | Genomic DNA |