D4GTA5 · NREA_HALVD

Function

function

Involved in DNA damage repair. Works together with the UvrABC proteins in repairing DNA damage resulting from exposure to the DNA damaging agent mitomycin C (MMC).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Biological ProcessDNA repair

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    DNA repair protein NreA
  • Alternative names
    • PCNA interacting protein NreA

Gene names

    • Name
      nreA
    • Ordered locus names
      HVO_0734

Organism names

Accessions

  • Primary accession
    D4GTA5

Proteomes

Phenotypes & Variants

Disruption phenotype

Non-essential, but cells lacking this gene are sensitive to DNA damage induced by treatment with MMC. Does not display increased sensitivity to UV light or to the alkylating agent methyl methanesulphonate (MMS).

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis411-420Displays increased chromosome fragmentation and delayed recovery relative to wild-type cells.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004425181-420DNA repair protein NreA

Proteomic databases

Interaction

Subunit

Interacts with the DNA polymerase sliding clamp (PCNA) via the PIP (PCNA-interacting peptide) motif.

Protein-protein interaction databases

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif413-420PIP motif

Sequence similarities

Belongs to the Nre family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    420
  • Mass (Da)
    46,864
  • Last updated
    2010-05-18 v1
  • Checksum
    4B84C16C6A9E6A7F
MRLDEYMDIERDERAERRRLAEEKSYGILDHLETFQDRFEETVQGDSLYGGVSPSIFVGRSNYPNVSTGILSPVGHDEDAASFETSAAWYDEGVSIDDVFQRRTSLLNSNRGTKVTNVADSWDGFLGTQREVAIADRPVTVEIGLDGKPSLDLDASADDVATPVGPRARARSADLAENPHVPKLVKKTLEDDDWNAEGAMTYLYRRGFDVYDINTILSAGALGQTEQRRLVPTRWSITAVDDTLGQYLRGQVKHAESVDGVEIYRNEFIGNAFWVILAPGRWEFELIELKAPGSVWNPDPEAGMYLAADREGYEGRTGYVNETAGAYHASRLGVLEHLQERGRQAKALVIRHVSDDYWGPVGVWQIRESIRHAFEGEMADAETFGDAVRDVTEYLPVSLADLRRKSTMAAGLQTDIFDFA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001956
EMBL· GenBank· DDBJ
ADE03741.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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