C7GND0 · HEK2_YEAS2
- ProteinHeterogeneous nuclear rnp K-like protein 2
- GeneHEK2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids381 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
RNA-binding protein involved in the correct localization of transcripts in the cell. RNA localization is a widespread mechanism for achieving localized protein synthesis. Required for the asymmetric localization to the daughter cell nucleus of the ASH1 transcript, coding for a specific repressor of transcription. Overexpression inhibits translation of the ASH1 transcript. Involved in the stability of transcripts, like the MTL1 mRNA. Involved in structural and functional organization of telomeric chromatin and regulates silencing at the HMR locus (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromosome, telomeric region | |
Cellular Component | nucleus | |
Cellular Component | P-body | |
Molecular Function | RNA binding | |
Biological Process | chromatin organization | |
Biological Process | mRNA transport | |
Biological Process | regulation of translation |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameHeterogeneous nuclear rnp K-like protein 2
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionC7GND0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000408193 | 1-381 | Heterogeneous nuclear rnp K-like protein 2 | |||
Sequence: MSQFFEAATPVAIPTNNTNGGSSDAGSAATGGAPVVGTTAQPTINHRLLLSLKEAAKIIGTKGSTISRIRAANSVKIGISEKVPGCSDRILSCAGNVINVANAIGDIVDVLNKRNPENEDAAEGEAEEHYYFHFLNHILPAPSKDEIRDLQQLEDIGYVRLIVANSHISSIIGKAGATIKSLINKHGVKIVASKDFLPASDERIIEIQGFPGSITNVLIEISEIILSDVDVRFSTERSYFPHLKKSSGEPTSPSTSSNTRIELKIPELYVGAIIGRGMNRIKNLKTFTKTNIVVERKDDDDKDENFRKFIITSKFPKNVKLAESMLLKNLNTEIEKRENYKRKLEAAEGDATVVTERSDSASFLEEKEEPQKNHDNKEEQS | ||||||
Modified residue | 358 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 360 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 362 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Phosphorylated by the plasma membrane-Anchored casein kinase YCK1. Phosphorylation at its C-terminus reduces its RNA-binding capacity (By similarity).
Keywords
- PTM
Interaction
Subunit
Binds RNA.
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-26 | Polar residues | ||||
Sequence: MSQFFEAATPVAIPTNNTNGGSSDAG | ||||||
Region | 1-34 | Disordered | ||||
Sequence: MSQFFEAATPVAIPTNNTNGGSSDAGSAATGGAP | ||||||
Domain | 43-107 | KH 1 | ||||
Sequence: TINHRLLLSLKEAAKIIGTKGSTISRIRAANSVKIGISEKVPGCSDRILSCAGNVINVANAIGDI | ||||||
Domain | 156-221 | KH 2 | ||||
Sequence: IGYVRLIVANSHISSIIGKAGATIKSLINKHGVKIVASKDFLPASDERIIEIQGFPGSITNVLIEI | ||||||
Domain | 258-326 | KH 3 | ||||
Sequence: NTRIELKIPELYVGAIIGRGMNRIKNLKTFTKTNIVVERKDDDDKDENFRKFIITSKFPKNVKLAESML | ||||||
Region | 344-381 | Disordered | ||||
Sequence: LEAAEGDATVVTERSDSASFLEEKEEPQKNHDNKEEQS | ||||||
Compositional bias | 360-381 | Basic and acidic residues | ||||
Sequence: SASFLEEKEEPQKNHDNKEEQS |
Sequence similarities
Belongs to the HEK2 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length381
- Mass (Da)41,698
- Last updated2009-10-13 v1
- ChecksumCAEAEEFBE6D77A5C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-26 | Polar residues | ||||
Sequence: MSQFFEAATPVAIPTNNTNGGSSDAG | ||||||
Compositional bias | 360-381 | Basic and acidic residues | ||||
Sequence: SASFLEEKEEPQKNHDNKEEQS |