C3K605 · LPXD_PSEFS
- ProteinUDP-3-O-acylglucosamine N-acyltransferase
- GenelpxD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids351 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Catalytic activity
- a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H+ + holo-[ACP]
Pathway
Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 240 | Proton acceptor | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | N-acyltransferase activity | |
Biological Process | lipid A biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUDP-3-O-acylglucosamine N-acyltransferase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionC3K605
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000211752 | 1-351 | UDP-3-O-acylglucosamine N-acyltransferase | |||
Sequence: MTATIKLGELAEFLGATLRGSPEKEITGLATLQEAGPAQLSFLANPQYRKYLVDSQAAAVLLKAADAEGFAGDALVVADPYLAYARVSHLFDPKPKAAAGVHPSAVIADDAQVDPAASIGAFAVVESGARIAAGVTVGAHCFIGARCEIGADGWLAPRVTLYHDVRIGERVVIQSGAVIGGEGFGFANAKGIWNKIAQVGGVLIGDDVEIGVNTAVDRGALADTVIGNGVKLDNQIQIAHNVQIGDHTAMAACVGISGSTKIGKHCMLAGGVGLVGHIDICDNVFITGMTMVTHSITEPGAYSSGTAMQPAAEWRKSAARLRQLDDMARRLKQLEKRVGDVTPGGNASSEG |
Interaction
Structure
Sequence
- Sequence statusComplete
- Length351
- Mass (Da)36,146
- Last updated2009-06-16 v1
- ChecksumFA53D50622B8771C