C1DHS5 · HIS3_AZOVD

Function

function

Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site77Mg2+ (UniProtKB | ChEBI)
Binding site78Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site79Mg2+ (UniProtKB | ChEBI)
Binding site81Mg2+ (UniProtKB | ChEBI)
Binding site95Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site102Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmagnesium ion binding
Molecular Functionphosphoribosyl-AMP cyclohydrolase activity
Molecular Functionzinc ion binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosyl-AMP cyclohydrolase
  • EC number
  • Short names
    PRA-CH

Gene names

    • Name
      hisI
    • Ordered locus names
      Avin_45440

Organism names

Accessions

  • Primary accession
    C1DHS5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10002132981-133Phosphoribosyl-AMP cyclohydrolase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the PRA-CH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    133
  • Mass (Da)
    15,404
  • Last updated
    2009-05-26 v1
  • Checksum
    7370C530DD2ED43D
MKDWLDEIHWNADGLVPAIAQDHRTGRILMMAWMNRESLALTVRENRAIYWSRSRGKLWRKGEESGHVQKVHELRLDCDADVIILQVEQLGGIACHTGRESCFYRVFEDGAWKVVDPILKDPDAIYRAGHPHE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001157
EMBL· GenBank· DDBJ
ACO80658.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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