C1CSH7 · DAPB_STRZT
- Protein4-hydroxy-tetrahydrodipicolinate reductase
- GenedapB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids255 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
Catalytic activity
- (S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD+ = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + NADH
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 9-14 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GFKGKM | ||||||
Binding site | 35 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 89-91 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GTT | ||||||
Binding site | 115-118 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: APNF | ||||||
Active site | 145 | Proton donor/acceptor | ||||
Sequence: H | ||||||
Binding site | 146 | (S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Active site | 149 | Proton donor | ||||
Sequence: K | ||||||
Binding site | 155-156 | (S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI) | ||||
Sequence: GT |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 4-hydroxy-tetrahydrodipicolinate reductase | |
Molecular Function | NAD binding | |
Molecular Function | NADP binding | |
Molecular Function | oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor | |
Biological Process | diaminopimelate biosynthetic process | |
Biological Process | lysine biosynthetic process via diaminopimelate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxy-tetrahydrodipicolinate reductase
- EC number
- Short namesHTPA reductase
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus
Accessions
- Primary accessionC1CSH7
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000189760 | 1-255 | 4-hydroxy-tetrahydrodipicolinate reductase | |||
Sequence: MSIRVIIAGFKGKMGQAACQMVLTDPDLDLVAVLDPFESESEWQGIPVFKDKADLAGFEADVWVDFTTPAVAYENTRFALENGFAPVVGTTGFTSEEIAELKEFSRAQDLGGLIAPNFALGAVLLMQFATQAAKYFPNVEIIELHHDKKKDAPSGTAIKTAELMAEVRESIQQGAADEEELIAGARGADFDGMRIHSVRLPGLVAHQEVIFGNQGEGLTLRHDSYDRISFMTGVNLGIKEVVKRHELVYGLEHLL |
Structure
Sequence
- Sequence statusComplete
- Length255
- Mass (Da)27,837
- Last updated2009-05-26 v1
- ChecksumBDE4464A11633BC5
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000921 EMBL· GenBank· DDBJ | ACO24090.1 EMBL· GenBank· DDBJ | Genomic DNA |