C1ATC6 · MSHD_RHOOB
- ProteinMycothiol acetyltransferase
- GenemshD
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids305 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
Catalytic activity
- 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = CoA + H+ + mycothiol
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 38 | 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 82-84 | acetyl-CoA 1 (UniProtKB | ChEBI) | ||||
Sequence: LAV | ||||||
Binding site | 183 | 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 225 | 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 238 | 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 242-244 | acetyl-CoA 2 (UniProtKB | ChEBI) | ||||
Sequence: VAI | ||||||
Binding site | 249-255 | acetyl-CoA 2 (UniProtKB | ChEBI) | ||||
Sequence: QGRGLGR | ||||||
Binding site | 276 | 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 281-286 | acetyl-CoA 2 (UniProtKB | ChEBI) | ||||
Sequence: NASALH |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | mycothiol synthase activity | |
Molecular Function | peptide-alanine-alpha-N-acetyltransferase activity | |
Biological Process | mycothiol biosynthetic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMycothiol acetyltransferase
- EC number
- Short namesMSH acetyltransferase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Nocardiaceae > Rhodococcus
Accessions
- Primary accessionC1ATC6
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000400291 | 1-305 | Mycothiol acetyltransferase | |||
Sequence: MSASVQSWTDRLDGAQAADVSALLGRATAADGTAPVSEQGVHAVSGAGGDGVRHLVETDADRIVGYAQLQPGHGEHPAMAELAVDPEARGRGIGGRLVAEVLSAGGPDTRVWAHGNLPAAQAVAQRLGLTGARELLQLRRPLAGAELPELVVLEGISLRVYRGVEDDPEVLRVNAAAFAWHPEQGSWTEREMAERRAEAWFDPAGLFMAFATSDEKRLLGFHWTKVHPKQGDEPAIGEVYVVAIGPDAQGRGLGRLLTLAGLHYLRDRGLGAVLLYVEGDNASALHTYDRLGFERFHTDVAYARA |
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 10-154 | N-acetyltransferase 1 | ||||
Sequence: DRLDGAQAADVSALLGRATAADGTAPVSEQGVHAVSGAGGDGVRHLVETDADRIVGYAQLQPGHGEHPAMAELAVDPEARGRGIGGRLVAEVLSAGGPDTRVWAHGNLPAAQAVAQRLGLTGARELLQLRRPLAGAELPELVVLE | ||||||
Domain | 156-305 | N-acetyltransferase 2 | ||||
Sequence: ISLRVYRGVEDDPEVLRVNAAAFAWHPEQGSWTEREMAERRAEAWFDPAGLFMAFATSDEKRLLGFHWTKVHPKQGDEPAIGEVYVVAIGPDAQGRGLGRLLTLAGLHYLRDRGLGAVLLYVEGDNASALHTYDRLGFERFHTDVAYARA |
Sequence similarities
Belongs to the acetyltransferase family. MshD subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length305
- Mass (Da)32,538
- Last updated2009-05-26 v1
- Checksum8703BC2C84F15833
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP011115 EMBL· GenBank· DDBJ | BAH53190.1 EMBL· GenBank· DDBJ | Genomic DNA |