C0Q7R1 · AROL_SALPC
- ProteinShikimate kinase 2
- GenearoL
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids181 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Catalytic activity
- ATP + shikimate = 3-phosphoshikimate + ADP + H+
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 12-17 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GCGKTT | ||||||
Binding site | 16 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 32 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 34 | substrate | ||||
Sequence: D | ||||||
Binding site | 58 | substrate | ||||
Sequence: R | ||||||
Binding site | 79 | substrate | ||||
Sequence: G | ||||||
Binding site | 120 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 139 | substrate | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | shikimate kinase activity | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameShikimate kinase 2
- EC number
- Short namesSK 2
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella
Accessions
- Primary accessionC0Q7R1
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000165147 | 1-181 | Shikimate kinase 2 | |||
Sequence: MMQPLYLVGPRGCGKTTIGMALAQATGFRFADTDRWLQSHVQMSVADIVEKEGWGGFRARETAALEAVSAPSTVVATGGGIILTDYNRRYMHRVGVVIYLCAPVSTLVNRLEAEPEADLRPTLTGKPLSEEVREVLEQRDALYRETAHYIIDATKAPAQVVSEIIAALPPSTQRLQGDVYT |
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 112-126 | LID domain | ||||
Sequence: EAEPEADLRPTLTGK |
Domain
The LID domain closes over the active site upon ATP binding.
Sequence similarities
Belongs to the shikimate kinase family. AroL subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length181
- Mass (Da)19,790
- Last updated2009-05-05 v1
- ChecksumF36E03687EF46FFC
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000857 EMBL· GenBank· DDBJ | ACN44581.1 EMBL· GenBank· DDBJ | Genomic DNA |