C0HKB3 · KKX29_PANIM

Function

function

Reversibly blocks voltage-gated potassium channels Kv1.2/KCNA2 and Kv1.3/KCNA3.

Miscellaneous

Negative results: does not inhibit voltage-gated potassium channels Shaker B, Shab, Kv1.1/KCNA1 and Kv1.4/KCNA4.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionpotassium channel regulator activity
Molecular Functiontoxin activity
Biological Processnegative regulation of voltage-gated potassium channel activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Potassium channel toxin kappa-KTx 2.9
  • Alternative names
    • Potassium channel-blocking toxin 6
      (Pi6
      )

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Scorpiones > Iurida > Scorpionoidea > Scorpionidae > Pandininae > Pandinus

Accessions

  • Primary accession
    C0HKB3

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for peptide, disulfide bond.

TypeIDPosition(s)Description
PeptidePRO_00004441661-28Potassium channel toxin kappa-KTx 2.9
Disulfide bond4↔22
Disulfide bond8↔18

Post-translational modification

Contains 2 disulfide bonds.

Keywords

Expression

Tissue specificity

Expressed by the venom gland.

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    28
  • Mass (Da)
    3,131
  • Last updated
    2018-05-23 v1
  • Checksum
    69CBD5B340915A6A
VDACYEACMHHHMNSDDCIEACKNPVPP

Mass Spectrometry

Molecular mass is 3,126.5 Da. Determined by Unknown.

Keywords

Similar Proteins

Disclaimer

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