C0H559 · ATAT_PLAF7

Function

function

Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.

Catalytic activity

Features

Showing features for site, binding site.

118420406080100120140160180
TypeIDPosition(s)Description
Site46Crucial for catalytic activity
Binding site104-117acetyl-CoA (UniProtKB | ChEBI)
Binding site140-149acetyl-CoA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmicrotubule
Molecular Functiontubulin N-acetyltransferase activity
Biological Processregulation of microtubule cytoskeleton organization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Alpha-tubulin N-acetyltransferase
  • EC number
  • Short names
    Alpha-TAT
    ; TAT
  • Alternative names
    • Acetyltransferase mec-17 homolog

Gene names

    • Name
      ATAT
    • ORF names
      PF3D7_0924900, PFI1220w

Organism names

Accessions

  • Primary accession
    C0H559

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004020781-184Alpha-tubulin N-acetyltransferase

Proteomic databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-170N-acetyltransferase

Sequence similarities

Belongs to the acetyltransferase ATAT1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    184
  • Mass (Da)
    21,835
  • Last updated
    2021-09-29 v2
  • Checksum
    124D7ACFA3F99A47
METFNHIDIKKYTREDLLYLRNTNNVLFKMFQKQVDEIACLSSKEQKLCGTLTSINNIINENYTIYCLIHTDGLIGFIKIGEKNLYLYDKIKLHYGKCTCVLDFYILEKFQKRGLGIKIFNFMLKDNDISAFCLCYDNPSYKLQNFLKKYFSPCVLIKQPNHFVIFSNYFKNVSIKKVYERISN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL844508
EMBL· GenBank· DDBJ
CAX64236.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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