C0H559 · ATAT_PLAF7
- ProteinAlpha-tubulin N-acetyltransferase
- GeneATAT
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids184 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.
Catalytic activity
- acetyl-CoA + L-lysyl-[alpha-tubulin] = CoA + H+ + N6-acetyl-L-lysyl-[alpha-tubulin]
Features
Showing features for site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | microtubule | |
Molecular Function | tubulin N-acetyltransferase activity | |
Biological Process | regulation of microtubule cytoskeleton organization |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlpha-tubulin N-acetyltransferase
- EC number
- Short namesAlpha-TAT ; TAT
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Laverania)
Accessions
- Primary accessionC0H559
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000402078 | 1-184 | Alpha-tubulin N-acetyltransferase | |||
Sequence: METFNHIDIKKYTREDLLYLRNTNNVLFKMFQKQVDEIACLSSKEQKLCGTLTSINNIINENYTIYCLIHTDGLIGFIKIGEKNLYLYDKIKLHYGKCTCVLDFYILEKFQKRGLGIKIFNFMLKDNDISAFCLCYDNPSYKLQNFLKKYFSPCVLIKQPNHFVIFSNYFKNVSIKKVYERISN |
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-170 | N-acetyltransferase | ||||
Sequence: METFNHIDIKKYTREDLLYLRNTNNVLFKMFQKQVDEIACLSSKEQKLCGTLTSINNIINENYTIYCLIHTDGLIGFIKIGEKNLYLYDKIKLHYGKCTCVLDFYILEKFQKRGLGIKIFNFMLKDNDISAFCLCYDNPSYKLQNFLKKYFSPCVLIKQPNHFVIFSNYF |
Sequence similarities
Belongs to the acetyltransferase ATAT1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length184
- Mass (Da)21,835
- Last updated2021-09-29 v2
- Checksum124D7ACFA3F99A47
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL844508 EMBL· GenBank· DDBJ | CAX64236.2 EMBL· GenBank· DDBJ | Genomic DNA |