B9WYE6 · VRDA_ASPPA
- ProteinVersiconal hemiacetal acetate reductase
- GenevrdA
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids343 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes 3 reactions: from hydroxyversicolorone (HVN) to versicolorone (VONE), from versiconal hemiacetal acetate (VHA) to versiconol acetate (VOAc) and from versiconal (VHOH) to versiconol (VOH). Probably not an aflatoxin biosynthesis gene: may be involved in the vertical branching steps connecting the main pathway from HVN to VHOH with the side pathway from VONE to VOH.
Catalytic activity
- (2S)-versicolorone + NADP+ = 1'-hydroxyversicolorone + H+ + NADPH
Features
Showing features for active site, site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | hydroxyversicolorone reductase activity | |
Molecular Function | versiconal hemiacetal acetate reductase activity | |
Molecular Function | versiconal reductase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameVersiconal hemiacetal acetate reductase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati
Accessions
- Primary accessionB9WYE6
Organism-specific databases
Phenotypes & Variants
Disruption phenotype
Aflatoxin production is not inhibited, while the enzyme activity catalyzing the reaction from versiconal hemiacetal acetate (VHA), to versiconol acetate (VOAc), which branches from the main pathway, significantly decreases.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000424161 | 1-343 | Versiconal hemiacetal acetate reductase | |||
Sequence: MEYARLGDSGLKVSKVILGCMGYGSPEWQGWVLNEEESLPLIEHAYNKGIRTWDTADMYSHGKSEEIVGKALKKYNIPRSRVVILTKCYFGVDDQGNFPSPLSTGRQNEGDYLNRVGLSRRHILEAVDASVERLGTYIDVLQIHRLDRETPREEIMRALNDVVESGKARYIGASSMAAWEFQTLQNIAIRNGWHKFISMQNYHNLIAREEEREMIPYCLDSGVSLIPWSPVARGALARPWASRSTLRENTDAGISILVRARESESDKAIIDRVEELADKKGISMAQVAIAWSLSHPSEYPIVGLNTKDRIDEAVASVQVKLTPEEIQYLEEPYVPKAIHPGER |
Structure
Family & Domains
Sequence similarities
Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length343
- Mass (Da)38,698
- Last updated2009-04-14 v1
- Checksum32AA44AEE1DEDAA3
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB025578 EMBL· GenBank· DDBJ | BAH24200.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB025579 EMBL· GenBank· DDBJ | BAH24201.1 EMBL· GenBank· DDBJ | mRNA |