B9WYE6 · VRDA_ASPPA

  • Protein
    Versiconal hemiacetal acetate reductase
  • Gene
    vrdA
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Catalyzes 3 reactions: from hydroxyversicolorone (HVN) to versicolorone (VONE), from versiconal hemiacetal acetate (VHA) to versiconol acetate (VOAc) and from versiconal (VHOH) to versiconol (VOH). Probably not an aflatoxin biosynthesis gene: may be involved in the vertical branching steps connecting the main pathway from HVN to VHOH with the side pathway from VONE to VOH.

Catalytic activity

Features

Showing features for active site, site, binding site.

TypeIDPosition(s)Description
Active site59Proton donor
Site87Lowers pKa of active site Tyr
Binding site144substrate
Binding site229-239NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionhydroxyversicolorone reductase activity
Molecular Functionversiconal hemiacetal acetate reductase activity
Molecular Functionversiconal reductase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Versiconal hemiacetal acetate reductase
  • EC number
  • Alternative names
    • VHA reductase

Gene names

    • Name
      vrdA

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC 26691 / NRRL 2999 / CBS 921.70
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati

Accessions

  • Primary accession
    B9WYE6

Organism-specific databases

Phenotypes & Variants

Disruption phenotype

Aflatoxin production is not inhibited, while the enzyme activity catalyzing the reaction from versiconal hemiacetal acetate (VHA), to versiconol acetate (VOAc), which branches from the main pathway, significantly decreases.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004241611-343Versiconal hemiacetal acetate reductase

Structure

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    343
  • Mass (Da)
    38,698
  • Last updated
    2009-04-14 v1
  • Checksum
    32AA44AEE1DEDAA3
MEYARLGDSGLKVSKVILGCMGYGSPEWQGWVLNEEESLPLIEHAYNKGIRTWDTADMYSHGKSEEIVGKALKKYNIPRSRVVILTKCYFGVDDQGNFPSPLSTGRQNEGDYLNRVGLSRRHILEAVDASVERLGTYIDVLQIHRLDRETPREEIMRALNDVVESGKARYIGASSMAAWEFQTLQNIAIRNGWHKFISMQNYHNLIAREEEREMIPYCLDSGVSLIPWSPVARGALARPWASRSTLRENTDAGISILVRARESESDKAIIDRVEELADKKGISMAQVAIAWSLSHPSEYPIVGLNTKDRIDEAVASVQVKLTPEEIQYLEEPYVPKAIHPGER

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB025578
EMBL· GenBank· DDBJ
BAH24200.1
EMBL· GenBank· DDBJ
Genomic DNA
AB025579
EMBL· GenBank· DDBJ
BAH24201.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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