B9JJJ9 · MURQ_RHIR8

Function

function

Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

Miscellaneous

A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.

Catalytic activity

Pathway

Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation.
Amino-sugar metabolism; N-acetylmuramate degradation.
Cell wall biogenesis; peptidoglycan recycling.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site90Proton donor
Active site121

GO annotations

AspectTerm
Molecular Functioncarbohydrate derivative binding
Molecular Functioncarbon-oxygen lyase activity
Molecular Functionether hydrolase activity
Biological Process1,6-anhydro-N-acetyl-beta-muramic acid catabolic process
Biological Processamino sugar catabolic process
Biological ProcessN-acetylmuramic acid catabolic process
Biological Processpeptidoglycan turnover

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N-acetylmuramic acid 6-phosphate etherase
  • EC number
  • Short names
    MurNAc-6-P etherase
  • Alternative names
    • N-acetylmuramic acid 6-phosphate hydrolase
    • N-acetylmuramic acid 6-phosphate lyase

Gene names

    • Name
      murQ
    • Ordered locus names
      Arad_8937

Organism names

Accessions

  • Primary accession
    B9JJJ9

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001180041-307N-acetylmuramic acid 6-phosphate etherase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain62-225SIS

Sequence similarities

Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    307
  • Mass (Da)
    32,321
  • Last updated
    2009-03-24 v1
  • Checksum
    4BFBDE7631B7E833
MTEQRLISELEQLVSEGRNPNTMHIDLLPTFDILREINYEDQTVPTAVEKVIPAIAAAVNQIVAAFQKGGRLIYMGAGTSGRLGVLDASECPPTFSVPSDMVIGLIAGGPEALQNSIEGAEDDPEQGRQALQDIKLTSTDVVVGIAVSGRTPYVIGGLNYAKSIGAVTIALSCNPNSIIAGIADLAISPVVGPEILTGSTRLKSGTAQKLILNMLTTASMIRIGKSYQNLMVDVHASNKKLVARAIRIVMQATGCTQADARRVLDQTGNDVKLAILMEITGMGIEEARAALQNAGGFLRKAISAKTA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000629
EMBL· GenBank· DDBJ
ACM30091.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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