B8YD37 · B8YD37_RHIHR

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • EURPor19
    • USALou12
    • USALou13
    • USALou17
    • USALou20
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Malacostraca > Eumalacostraca > Eucarida > Decapoda > Pleocyemata > Brachyura > Eubrachyura > Xanthoidea > Panopeidae > Rhithropanopeus

Accessions

  • Primary accession
    B8YD37

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane23-46Helical
Transmembrane67-91Helical
Transmembrane111-134Helical
Transmembrane146-173Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-174Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    174
  • Mass (Da)
    18,575
  • Last updated
    2009-03-03 v1
  • Checksum
    FF0D01366C9359E7
RAELGQPGTLIGNDQIYNVVVTAHAFVMIFLMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPSLTLLLMSGMVESGVGTGWTVYPPLAAAIAHAGASVDMGIFSLHLAGVSSILGAVNFMTTVINMRSFGMTMDQMPLFVWAVFITAILLLLSLPVLAGAITMLLT

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue174

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FJ517453
EMBL· GenBank· DDBJ
ACL36200.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ517509
EMBL· GenBank· DDBJ
ACL36256.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ517525
EMBL· GenBank· DDBJ
ACL36272.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ517526
EMBL· GenBank· DDBJ
ACL36273.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ517527
EMBL· GenBank· DDBJ
ACL36274.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ517528
EMBL· GenBank· DDBJ
ACL36275.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ517529
EMBL· GenBank· DDBJ
ACL36276.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ517531
EMBL· GenBank· DDBJ
ACL36278.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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