B8R118 · B8R118_TAMSI

Function

function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.

Cofactor

Protein has several cofactor binding sites:
heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 2 heme groups non-covalently.
heme (UniProtKB | Rhea| CHEBI:30413 )

Note: Binds 2 heme groups non-covalently.

Features

Showing features for binding site.

137950100150200250300350
TypeIDPosition(s)Description
Binding site83Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site97Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site182Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site196Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site201a ubiquinone (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial respiratory chain complex III
Molecular Functionmetal ion binding
Molecular Functionubiquinol-cytochrome-c reductase activity
Biological Processmitochondrial electron transport, ubiquinol to cytochrome c

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome b

Gene names

    • Name
      cytb

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • Cgrb1129
    • Cgrb1144
    • Cgrb1151
    • Cgrb1213
    • Cgrb1276
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Sciuromorpha > Sciuridae > Xerinae > Marmotini > Tamias

Accessions

  • Primary accession
    B8R118

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-52Helical
Transmembrane87-107Helical
Transmembrane113-133Helical
Transmembrane145-166Helical
Transmembrane178-200Helical
Transmembrane229-246Helical
Transmembrane288-307Helical
Transmembrane319-340Helical
Transmembrane346-372Helical

Keywords

Interaction

Subunit

The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-209Cytochrome b/b6 N-terminal region profile
Domain210-379Cytochrome b/b6 C-terminal region profile

Sequence similarities

Belongs to the cytochrome b family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    379
  • Mass (Da)
    43,085
  • Last updated
    2009-03-03 v1
  • Checksum
    E4A703B80023326B
MTNIRKTHPLIKIINHSFIDLPAPSNISAWWNFGSLLGICLIIQIITGLFLAMHYTSDTLTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGLYYGSYTYFETWNIGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVMIHLLFLHETGSNNPSGLISDSDKIPFHPYYTIKDILGMLLLLLFLMILVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILMLFPILHTSKQRSMMFRPLSQCMFWILVADLLTLTWIGGQPVEHPFIIIGQLASILYFSIILLIMPTISLFENKLLKW

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU754782
EMBL· GenBank· DDBJ
ACI15167.1
EMBL· GenBank· DDBJ
Genomic DNA
EU754783
EMBL· GenBank· DDBJ
ACI15168.1
EMBL· GenBank· DDBJ
Genomic DNA
EU754784
EMBL· GenBank· DDBJ
ACI15169.1
EMBL· GenBank· DDBJ
Genomic DNA
EU754785
EMBL· GenBank· DDBJ
ACI15170.1
EMBL· GenBank· DDBJ
Genomic DNA
EU754786
EMBL· GenBank· DDBJ
ACI15171.1
EMBL· GenBank· DDBJ
Genomic DNA
EU754788
EMBL· GenBank· DDBJ
ACI15173.1
EMBL· GenBank· DDBJ
Genomic DNA
EU754795
EMBL· GenBank· DDBJ
ACI15180.1
EMBL· GenBank· DDBJ
Genomic DNA
EU754796
EMBL· GenBank· DDBJ
ACI15181.1
EMBL· GenBank· DDBJ
Genomic DNA
EU754797
EMBL· GenBank· DDBJ
ACI15182.1
EMBL· GenBank· DDBJ
Genomic DNA
EU754800
EMBL· GenBank· DDBJ
ACI15185.1
EMBL· GenBank· DDBJ
Genomic DNA
EU754805
EMBL· GenBank· DDBJ
ACI15190.1
EMBL· GenBank· DDBJ
Genomic DNA
EU754808
EMBL· GenBank· DDBJ
ACI15193.1
EMBL· GenBank· DDBJ
Genomic DNA
EU754810
EMBL· GenBank· DDBJ
ACI15195.1
EMBL· GenBank· DDBJ
Genomic DNA
EU754811
EMBL· GenBank· DDBJ
ACI15196.1
EMBL· GenBank· DDBJ
Genomic DNA
EU754812
EMBL· GenBank· DDBJ
ACI15197.1
EMBL· GenBank· DDBJ
Genomic DNA
EU754813
EMBL· GenBank· DDBJ
ACI15198.1
EMBL· GenBank· DDBJ
Genomic DNA
EU754816
EMBL· GenBank· DDBJ
ACI15201.1
EMBL· GenBank· DDBJ
Genomic DNA
EU754817
EMBL· GenBank· DDBJ
ACI15202.1
EMBL· GenBank· DDBJ
Genomic DNA
EU754820
EMBL· GenBank· DDBJ
ACI15205.1
EMBL· GenBank· DDBJ
Genomic DNA
EU754822
EMBL· GenBank· DDBJ
ACI15207.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ214034
EMBL· GenBank· DDBJ
AEM65164.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ214036
EMBL· GenBank· DDBJ
AEM65166.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ214037
EMBL· GenBank· DDBJ
AEM65167.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ214038
EMBL· GenBank· DDBJ
AEM65168.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ214039
EMBL· GenBank· DDBJ
AEM65169.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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