B8GF03 · PYRB_METPE

Function

function

Catalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway.

Catalytic activity

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.

Features

Showing features for binding site.

129820406080100120140160180200220240260280
TypeIDPosition(s)Description
Binding site50carbamoyl phosphate (UniProtKB | ChEBI)
Binding site51carbamoyl phosphate (UniProtKB | ChEBI)
Binding site79L-aspartate (UniProtKB | ChEBI)
Binding site100carbamoyl phosphate (UniProtKB | ChEBI)
Binding site128carbamoyl phosphate (UniProtKB | ChEBI)
Binding site131carbamoyl phosphate (UniProtKB | ChEBI)
Binding site160L-aspartate (UniProtKB | ChEBI)
Binding site221L-aspartate (UniProtKB | ChEBI)
Binding site260carbamoyl phosphate (UniProtKB | ChEBI)
Binding site261carbamoyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionamino acid binding
Molecular Functionaspartate carbamoyltransferase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processamino acid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aspartate carbamoyltransferase catalytic subunit
  • EC number
  • Alternative names
    • Aspartate transcarbamylase
      (ATCase
      )

Gene names

    • Name
      pyrB
    • Ordered locus names
      Mpal_2536

Organism names

Accessions

  • Primary accession
    B8GF03

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001161501-298Aspartate carbamoyltransferase catalytic subunit

Interaction

Subunit

Heterooligomer of catalytic and regulatory chains.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    298
  • Mass (Da)
    33,265
  • Last updated
    2009-03-03 v1
  • Checksum
    755EFA648CD1F53E
MKDFISIRDFDRAAIDRLIAEAERIDHHQYDPLEMKGKILALLFFEPSTRTRMSFEAAMARLGGTSLTLSSFEASSMAKGETLADTIRVVSGYVDAIVLRHPREGAARLASEVSSVPVINAGDGAGQHPSQTLLDLYTIRQSMPIDGINIGLLGDLRYGRTTHSLTYALSLYDAVIHTVAPAGLNLPSGLVHELRELGTEVIEHEQIEDVIKELDVLYVTRIQRERFPDTASYFNVASSYRITPELLRGTKEHMVVLHPLPRVDEIDPRVDKMKNARYFEQSHNGVPVRMAMLKQVIA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001338
EMBL· GenBank· DDBJ
ACL17809.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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