B6UZ97 · B6UZ97_9NEOP
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids156 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Lepidoptera > Glossata > Ditrysia > Tortricoidea > Tortricidae > Tortricinae > Ctenopseustis
Accessions
- Primary accessionB6UZ97
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 60-86 | Helical | ||||
Sequence: LAIFSLHLAGISSILGAVNFITTIINM | ||||||
Transmembrane | 98-125 | Helical | ||||
Sequence: LFVWAVGITALLLLLSLPVLAGAITMLL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-30 | |||||
Sequence: MLGAPDMAFPRMNNMSFWLLPPSIMLLISS | ||||||
Chain | PRO_5007644282 | 31-156 | Cytochrome c oxidase subunit 1 | |||
Sequence: SIVENGAGTGWTVYPPLSSNIAHSGSSVDLAIFSLHLAGISSILGAVNFITTIINMRPNNMSLDQMPLFVWAVGITALLLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHP |
Interaction
Subunit
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-156 | Cytochrome oxidase subunit I profile | ||||
Sequence: MLGAPDMAFPRMNNMSFWLLPPSIMLLISSSIVENGAGTGWTVYPPLSSNIAHSGSSVDLAIFSLHLAGISSILGAVNFITTIINMRPNNMSLDQMPLFVWAVGITALLLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHP |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length156
- Mass (Da)16,819
- Last updated2008-12-16 v1
- Checksum6690374D9C4FA1BF
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: M | ||||||
Non-terminal residue | 156 | |||||
Sequence: P |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FJ225474 EMBL· GenBank· DDBJ | ACJ08743.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225475 EMBL· GenBank· DDBJ | ACJ08744.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225476 EMBL· GenBank· DDBJ | ACJ08745.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225477 EMBL· GenBank· DDBJ | ACJ08746.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225478 EMBL· GenBank· DDBJ | ACJ08747.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225479 EMBL· GenBank· DDBJ | ACJ08748.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225480 EMBL· GenBank· DDBJ | ACJ08749.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225481 EMBL· GenBank· DDBJ | ACJ08750.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225482 EMBL· GenBank· DDBJ | ACJ08751.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225483 EMBL· GenBank· DDBJ | ACJ08752.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225484 EMBL· GenBank· DDBJ | ACJ08753.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225485 EMBL· GenBank· DDBJ | ACJ08754.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225486 EMBL· GenBank· DDBJ | ACJ08755.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225487 EMBL· GenBank· DDBJ | ACJ08756.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225488 EMBL· GenBank· DDBJ | ACJ08757.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225489 EMBL· GenBank· DDBJ | ACJ08758.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225490 EMBL· GenBank· DDBJ | ACJ08759.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225491 EMBL· GenBank· DDBJ | ACJ08760.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225492 EMBL· GenBank· DDBJ | ACJ08761.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225493 EMBL· GenBank· DDBJ | ACJ08762.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225494 EMBL· GenBank· DDBJ | ACJ08763.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225495 EMBL· GenBank· DDBJ | ACJ08764.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225496 EMBL· GenBank· DDBJ | ACJ08765.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225497 EMBL· GenBank· DDBJ | ACJ08766.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225498 EMBL· GenBank· DDBJ | ACJ08767.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225499 EMBL· GenBank· DDBJ | ACJ08768.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225500 EMBL· GenBank· DDBJ | ACJ08769.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225501 EMBL· GenBank· DDBJ | ACJ08770.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225502 EMBL· GenBank· DDBJ | ACJ08771.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225503 EMBL· GenBank· DDBJ | ACJ08772.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225504 EMBL· GenBank· DDBJ | ACJ08773.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225505 EMBL· GenBank· DDBJ | ACJ08774.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225507 EMBL· GenBank· DDBJ | ACJ08776.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225508 EMBL· GenBank· DDBJ | ACJ08777.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225509 EMBL· GenBank· DDBJ | ACJ08778.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225510 EMBL· GenBank· DDBJ | ACJ08779.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225511 EMBL· GenBank· DDBJ | ACJ08780.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225512 EMBL· GenBank· DDBJ | ACJ08781.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225513 EMBL· GenBank· DDBJ | ACJ08782.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225514 EMBL· GenBank· DDBJ | ACJ08783.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225515 EMBL· GenBank· DDBJ | ACJ08784.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225516 EMBL· GenBank· DDBJ | ACJ08785.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225518 EMBL· GenBank· DDBJ | ACJ08787.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225519 EMBL· GenBank· DDBJ | ACJ08788.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225521 EMBL· GenBank· DDBJ | ACJ08790.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225522 EMBL· GenBank· DDBJ | ACJ08791.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225523 EMBL· GenBank· DDBJ | ACJ08792.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225524 EMBL· GenBank· DDBJ | ACJ08793.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225525 EMBL· GenBank· DDBJ | ACJ08794.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225526 EMBL· GenBank· DDBJ | ACJ08795.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225527 EMBL· GenBank· DDBJ | ACJ08796.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225528 EMBL· GenBank· DDBJ | ACJ08797.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225566 EMBL· GenBank· DDBJ | ACJ08835.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225567 EMBL· GenBank· DDBJ | ACJ08836.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225568 EMBL· GenBank· DDBJ | ACJ08837.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225569 EMBL· GenBank· DDBJ | ACJ08838.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225570 EMBL· GenBank· DDBJ | ACJ08839.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225572 EMBL· GenBank· DDBJ | ACJ08841.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225573 EMBL· GenBank· DDBJ | ACJ08842.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225575 EMBL· GenBank· DDBJ | ACJ08844.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225576 EMBL· GenBank· DDBJ | ACJ08845.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225577 EMBL· GenBank· DDBJ | ACJ08846.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225578 EMBL· GenBank· DDBJ | ACJ08847.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225579 EMBL· GenBank· DDBJ | ACJ08848.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ225580 EMBL· GenBank· DDBJ | ACJ08849.1 EMBL· GenBank· DDBJ | Genomic DNA |