B6UZ97 · B6UZ97_9NEOP

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • C_obl_005
    • C_obl_007
    • C_obl_008
    • C_obl_009
    • C_obl_014
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Lepidoptera > Glossata > Ditrysia > Tortricoidea > Tortricidae > Tortricinae > Ctenopseustis

Accessions

  • Primary accession
    B6UZ97

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane60-86Helical
Transmembrane98-125Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-30
ChainPRO_500764428231-156Cytochrome c oxidase subunit 1

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-156Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    156
  • Mass (Da)
    16,819
  • Last updated
    2008-12-16 v1
  • Checksum
    6690374D9C4FA1BF
MLGAPDMAFPRMNNMSFWLLPPSIMLLISSSIVENGAGTGWTVYPPLSSNIAHSGSSVDLAIFSLHLAGISSILGAVNFITTIINMRPNNMSLDQMPLFVWAVGITALLLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHP

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue156

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FJ225474
EMBL· GenBank· DDBJ
ACJ08743.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225475
EMBL· GenBank· DDBJ
ACJ08744.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225476
EMBL· GenBank· DDBJ
ACJ08745.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225477
EMBL· GenBank· DDBJ
ACJ08746.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225478
EMBL· GenBank· DDBJ
ACJ08747.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225479
EMBL· GenBank· DDBJ
ACJ08748.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225480
EMBL· GenBank· DDBJ
ACJ08749.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225481
EMBL· GenBank· DDBJ
ACJ08750.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225482
EMBL· GenBank· DDBJ
ACJ08751.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225483
EMBL· GenBank· DDBJ
ACJ08752.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225484
EMBL· GenBank· DDBJ
ACJ08753.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225485
EMBL· GenBank· DDBJ
ACJ08754.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225486
EMBL· GenBank· DDBJ
ACJ08755.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225487
EMBL· GenBank· DDBJ
ACJ08756.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225488
EMBL· GenBank· DDBJ
ACJ08757.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225489
EMBL· GenBank· DDBJ
ACJ08758.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225490
EMBL· GenBank· DDBJ
ACJ08759.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225491
EMBL· GenBank· DDBJ
ACJ08760.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225492
EMBL· GenBank· DDBJ
ACJ08761.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225493
EMBL· GenBank· DDBJ
ACJ08762.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225494
EMBL· GenBank· DDBJ
ACJ08763.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225495
EMBL· GenBank· DDBJ
ACJ08764.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225496
EMBL· GenBank· DDBJ
ACJ08765.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225497
EMBL· GenBank· DDBJ
ACJ08766.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225498
EMBL· GenBank· DDBJ
ACJ08767.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225499
EMBL· GenBank· DDBJ
ACJ08768.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225500
EMBL· GenBank· DDBJ
ACJ08769.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225501
EMBL· GenBank· DDBJ
ACJ08770.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225502
EMBL· GenBank· DDBJ
ACJ08771.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225503
EMBL· GenBank· DDBJ
ACJ08772.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225504
EMBL· GenBank· DDBJ
ACJ08773.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225505
EMBL· GenBank· DDBJ
ACJ08774.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225507
EMBL· GenBank· DDBJ
ACJ08776.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225508
EMBL· GenBank· DDBJ
ACJ08777.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225509
EMBL· GenBank· DDBJ
ACJ08778.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225510
EMBL· GenBank· DDBJ
ACJ08779.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225511
EMBL· GenBank· DDBJ
ACJ08780.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225512
EMBL· GenBank· DDBJ
ACJ08781.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225513
EMBL· GenBank· DDBJ
ACJ08782.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225514
EMBL· GenBank· DDBJ
ACJ08783.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225515
EMBL· GenBank· DDBJ
ACJ08784.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225516
EMBL· GenBank· DDBJ
ACJ08785.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225518
EMBL· GenBank· DDBJ
ACJ08787.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225519
EMBL· GenBank· DDBJ
ACJ08788.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225521
EMBL· GenBank· DDBJ
ACJ08790.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225522
EMBL· GenBank· DDBJ
ACJ08791.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225523
EMBL· GenBank· DDBJ
ACJ08792.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225524
EMBL· GenBank· DDBJ
ACJ08793.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225525
EMBL· GenBank· DDBJ
ACJ08794.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225526
EMBL· GenBank· DDBJ
ACJ08795.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225527
EMBL· GenBank· DDBJ
ACJ08796.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225528
EMBL· GenBank· DDBJ
ACJ08797.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225566
EMBL· GenBank· DDBJ
ACJ08835.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225567
EMBL· GenBank· DDBJ
ACJ08836.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225568
EMBL· GenBank· DDBJ
ACJ08837.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225569
EMBL· GenBank· DDBJ
ACJ08838.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225570
EMBL· GenBank· DDBJ
ACJ08839.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225572
EMBL· GenBank· DDBJ
ACJ08841.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225573
EMBL· GenBank· DDBJ
ACJ08842.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225575
EMBL· GenBank· DDBJ
ACJ08844.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225576
EMBL· GenBank· DDBJ
ACJ08845.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225577
EMBL· GenBank· DDBJ
ACJ08846.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225578
EMBL· GenBank· DDBJ
ACJ08847.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225579
EMBL· GenBank· DDBJ
ACJ08848.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ225580
EMBL· GenBank· DDBJ
ACJ08849.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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