B6RAN7 · B6RAN7_9SPER

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    coxI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      coxI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 413
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Gnetopsida > Gnetidae > Ephedrales > Ephedraceae > Ephedra

Accessions

  • Primary accession
    B6RAN7

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-46Helical
Transmembrane67-89Helical
Transmembrane109-134Helical
Transmembrane146-173Helical
Transmembrane193-217Helical
Transmembrane229-253Helical
Transmembrane265-288Helical
Transmembrane300-321Helical
Transmembrane341-359Helical
Transmembrane371-392Helical
Transmembrane412-438Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-461Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    461
  • Mass (Da)
    50,182
  • Last updated
    2008-12-16 v1
  • Checksum
    F6423E2C1F0328F2
ELAQPGDQLVGGNHQLYNVLITAHAFLMIFFMVMPAVIGGFGNWFVPILIGAPDMAFPRLNNISLWLLPPSLLLLVSSALVEVGSGTGWTVYPPLNGITSHSGGSVDMAIFSLHLSGVSSILGSINFITTIFNMRGPGMTLHRLPLFVWSVLVTAFLLLCSIPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISQIVSTLSGKQVFGYLGMVYAMISIGVLGFMVWAHHMFTVGLDVDTRAYFTAATMIIAVPTGIKIFSWIATMWGGSIRSITPMLFAVGFLFLFTIGGLTGIVLANSGLDIALHDTYYVVAHFHYVLSMGAVFALFAGFYFWVGKLSGRTYPETVGQLHFWITFFGVNCTFFPMHFLGISGMPRRIPDYPDAYAGWNYLISFGSYVSVVGLVGFFVVVTLTLGNNIRAPLGPAFAPKPCNPTTPE

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue461

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EF053152
EMBL· GenBank· DDBJ
ABN50276.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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