B5FPR1 · FIEF_SALDC
- ProteinCation-efflux pump FieF
- GenefieF
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids300 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Divalent metal cation transporter which exports Zn2+, Cd2+ and possibly Fe2+. May be involved in zinc and iron detoxification by efflux.
Catalytic activity
- H+(out) + Zn2+(in) = H+(in) + Zn2+(out)
- Cd2+(in) + H+(out) = Cd2+(out) + H+(in)
- Fe2+(in) + H+(out) = Fe2+(out) + H+(in)
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | antiporter activity | |
Molecular Function | cadmium ion transmembrane transporter activity | |
Molecular Function | iron ion transmembrane transporter activity | |
Molecular Function | metal ion binding | |
Molecular Function | zinc ion transmembrane transporter activity |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCation-efflux pump FieF
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella
Accessions
- Primary accessionB5FPR1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 24-44 | Helical | ||||
Sequence: LLIKIFAWWYTGSVSILAALV | ||||||
Transmembrane | 82-102 | Helical | ||||
Sequence: AALAQSMFISGSALFLFLTSI | ||||||
Transmembrane | 114-134 | Helical | ||||
Sequence: PGVGIGVTVIALICTIILVTF | ||||||
Transmembrane | 156-176 | Helical | ||||
Sequence: SDVMMNGAILIALGLSWYGWH | ||||||
Transmembrane | 178-198 | Helical | ||||
Sequence: ADALFALGIGIYILYSALRMG |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000145700 | 1-300 | Cation-efflux pump FieF | |||
Sequence: MNQTYGRLVSRAAIAATAMASALLLIKIFAWWYTGSVSILAALVDSLVDIAASLTNLLVVRYSLQPADDEHTFGHGKAESLAALAQSMFISGSALFLFLTSIQNLIKPTPMNDPGVGIGVTVIALICTIILVTFQRWVVRKTQSQAVRADMLHYQSDVMMNGAILIALGLSWYGWHRADALFALGIGIYILYSALRMGYEAVQSLLDRALPDAERQEIIDIVTSWPGVSGAHDLRTRQSGPTRFIQIHLEMEDNLPLVQAHFVADQVEQAILQRFPGSDVIIHQDPCSVVPREGRKFELV |
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length300
- Mass (Da)32,974
- Last updated2008-10-14 v1
- Checksum32A5AE73F921786F
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001144 EMBL· GenBank· DDBJ | ACH76504.1 EMBL· GenBank· DDBJ | Genomic DNA |