B5A5F0 · B5A5F0_LUCSE

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • S1
    • S10
    • S11
    • S12
    • S13
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Oestroidea > Calliphoridae > Luciliinae > Lucilia

Accessions

  • Primary accession
    B5A5F0

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-28Helical
Transmembrane91-116Helical
Transmembrane128-155Helical
Transmembrane175-196Helical
Transmembrane217-236Helical
Transmembrane248-270Helical
Transmembrane282-304Helical
Transmembrane324-345Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-371Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    371
  • Mass (Da)
    40,543
  • Last updated
    2008-09-23 v1
  • Checksum
    EE8FB200DAFD4B0B
VIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPALTLLLVSSMVENGAGTGWTVYPPLSSNIAHGGASVDLAIFSLHLAGISSILGAVNFITTVINMRSTGITFDRMPLFVWSVVITALLLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIISQESGKKETFGSLGMIYAMLAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATLYGTQLNYSPATLWALGFVFLFTVGGLTGVVLANSSVDIILHDTYYVVAHFHYVLSMGAVFAIMAGFVHWYPLFTGLTLNTKMLKSQFAIMFIGVNLTFF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue371

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU815010
EMBL· GenBank· DDBJ
ACF36914.1
EMBL· GenBank· DDBJ
Genomic DNA
EU815011
EMBL· GenBank· DDBJ
ACF36915.1
EMBL· GenBank· DDBJ
Genomic DNA
EU815012
EMBL· GenBank· DDBJ
ACF36916.1
EMBL· GenBank· DDBJ
Genomic DNA
EU815013
EMBL· GenBank· DDBJ
ACF36917.1
EMBL· GenBank· DDBJ
Genomic DNA
EU815014
EMBL· GenBank· DDBJ
ACF36918.1
EMBL· GenBank· DDBJ
Genomic DNA
EU815015
EMBL· GenBank· DDBJ
ACF36919.1
EMBL· GenBank· DDBJ
Genomic DNA
EU815016
EMBL· GenBank· DDBJ
ACF36920.1
EMBL· GenBank· DDBJ
Genomic DNA
EU815017
EMBL· GenBank· DDBJ
ACF36921.1
EMBL· GenBank· DDBJ
Genomic DNA
EU815018
EMBL· GenBank· DDBJ
ACF36922.1
EMBL· GenBank· DDBJ
Genomic DNA
EU815019
EMBL· GenBank· DDBJ
ACF36923.1
EMBL· GenBank· DDBJ
Genomic DNA
EU815020
EMBL· GenBank· DDBJ
ACF36924.1
EMBL· GenBank· DDBJ
Genomic DNA
EU815024
EMBL· GenBank· DDBJ
ACF36928.1
EMBL· GenBank· DDBJ
Genomic DNA
EU815025
EMBL· GenBank· DDBJ
ACF36929.1
EMBL· GenBank· DDBJ
Genomic DNA
EU815026
EMBL· GenBank· DDBJ
ACF36930.1
EMBL· GenBank· DDBJ
Genomic DNA
EU815028
EMBL· GenBank· DDBJ
ACF36932.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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