B4NDL8 · NAAT1_DROWI
- ProteinSodium-dependent nutrient amino acid transporter 1
- GeneNAAT1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids641 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | amino acid:sodium symporter activity | |
Molecular Function | D-amino acid transmembrane transporter activity | |
Molecular Function | L-amino acid transmembrane transporter activity | |
Molecular Function | neutral L-amino acid transmembrane transporter activity | |
Biological Process | D-amino acid transport | |
Biological Process | neutral amino acid transport | |
Biological Process | sodium ion transport |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSodium-dependent nutrient amino acid transporter 1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionB4NDL8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-38 | Cytoplasmic | ||||
Sequence: MELKNIEQQPQLQNGNGTATENNEKGEQKPTEGGERTN | ||||||
Transmembrane | 39-59 | Helical; Name=1 | ||||
Sequence: WGNGLEFLMSCISVSVGLGNV | ||||||
Transmembrane | 72-92 | Helical; Name=2 | ||||
Sequence: GAFLIPYIIVLFLIGKPMYYL | ||||||
Transmembrane | 125-145 | Helical; Name=3 | ||||
Sequence: TVCIISYYSSLLALTLYYLFV | ||||||
Transmembrane | 229-249 | Helical; Name=4 | ||||
Sequence: PDWKLTLALLVSWIVTFLVIM | ||||||
Transmembrane | 258-278 | Helical; Name=5 | ||||
Sequence: AAYFLAIFPYVVLFVLLGRAV | ||||||
Transmembrane | 307-327 | Helical; Name=6 | ||||
Sequence: AVVQCFFSLAVSCGPIIMFAS | ||||||
Transmembrane | 341-361 | Helical; Name=7 | ||||
Sequence: IVTTLDTLTSLLGGITIFAIL | ||||||
Transmembrane | 401-421 | Helical; Name=8 | ||||
Sequence: LFSVLFFFMLFVLGIGSIVAL | ||||||
Transmembrane | 441-461 | Helical; Name=9 | ||||
Sequence: VALVTSICGFLLGLVYVTPGG | ||||||
Transmembrane | 474-494 | Helical; Name=10 | ||||
Sequence: TYVVFILAIFELAGIVWIYGL | ||||||
Transmembrane | 516-536 | Helical; Name=11 | ||||
Sequence: CWSFFTPVMMIIIFIYSMATI | ||||||
Transmembrane | 552-572 | Helical; Name=12 | ||||
Sequence: IAGWIVFAIGTAQFPLWGIWY |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000386589 | 1-641 | Sodium-dependent nutrient amino acid transporter 1 | |||
Sequence: MELKNIEQQPQLQNGNGTATENNEKGEQKPTEGGERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPYIIVLFLIGKPMYYLEMIIGQFTSQGSVKIWSICPSFLGVGYGQAFATVCIISYYSSLLALTLYYLFVSFQSVLPWSYCRDEWTNCVNSRPEDYSSTMLEAARNATSSLLIGNETTSLADNDSVQLQSSSELYFLNVVIKEKLDISDGVGAPDWKLTLALLVSWIVTFLVIMRGVKSSGKAAYFLAIFPYVVLFVLLGRAVTLEGAVDGIIFFLQPQWGELLNPTVWKEAVVQCFFSLAVSCGPIIMFASYNRFDHSIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQVDNIREVVRSGTGLAFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTIICDQFKSWKYWKVALVTSICGFLLGLVYVTPGGQWILTLVDFYGGTYVVFILAIFELAGIVWIYGLQNFCDDIEFMCNKRVSLYWRVCWSFFTPVMMIIIFIYSMATIEPLKYSDLYFPLAGDIAGWIVFAIGTAQFPLWGIWYISHHRNGNLWQSFVSCLKPNENWGPANPETKQAWLLFKSEKARQRASKTQSSKMGQFWQKVGNFCGSST | ||||||
Glycosylation | 181 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 190 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 198 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-24 | Polar residues | ||||
Sequence: MELKNIEQQPQLQNGNGTATENNE | ||||||
Region | 1-37 | Disordered | ||||
Sequence: MELKNIEQQPQLQNGNGTATENNEKGEQKPTEGGERT |
Sequence similarities
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length641
- Mass (Da)71,796
- Last updated2008-09-23 v1
- Checksum6D8C2C9B7CE2D953
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-24 | Polar residues | ||||
Sequence: MELKNIEQQPQLQNGNGTATENNE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH964239 EMBL· GenBank· DDBJ | EDW81840.1 EMBL· GenBank· DDBJ | Genomic DNA |