B3NSF6 · QVR_DROER
- ProteinUPAR/Ly6 domain-containing protein qvr
- Geneqvr
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids158 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Bifunctional regulator of neuronal activity in the mushroom body, and possibly other regions of the brain, that acts as a signaling molecule required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Reduces neuronal excitability by enhancing Sh/shaker K+ channel activity; possibly by stabilizing Sh/shaker to increase protein levels, accelerating its activation kinetics, slowing C-type inactivation and enhancing recovery from inactivation. Specifically affects the A-type K+ current. Antagonizes nicotinic acetylcholine receptors (nAChRs) to reduce synaptic transmission, possibly by preventing their localization to the cell surface. Required for regulation of neuromuscular excitability and plasticity at neuromuscular junctions.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | external side of plasma membrane | |
Cellular Component | membrane raft | |
Cellular Component | plasma membrane | |
Molecular Function | acetylcholine receptor inhibitor activity | |
Molecular Function | GPI anchor binding | |
Molecular Function | potassium channel activator activity | |
Biological Process | negative regulation of membrane potential | |
Biological Process | positive regulation of circadian sleep/wake cycle, sleep | |
Biological Process | regulation of circadian sleep/wake cycle, sleep | |
Biological Process | regulation of synaptic transmission, cholinergic | |
Biological Process | rhythmic process | |
Biological Process | sleep |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameUPAR/Ly6 domain-containing protein qvr
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionB3NSF6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Lipid-anchor, GPI-anchor
Membrane raft ; Lipid-anchor, GPI-anchor
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 136-156 | Helical | ||||
Sequence: GCQLHLIPIAVAVSWLMGQLL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation, lipidation, propeptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-32 | |||||
Sequence: MWTQRNAVGNWLLVLTAVIGFLTFIWIPQTSA | ||||||
Chain | PRO_0000365458 | 33-127 | UPAR/Ly6 domain-containing protein qvr | |||
Sequence: ECQTRSIYCYECDSWTDARCKDPFNYTALPRDQPPLMTCNGCCVKMVRHQRSPYEVVRRMCTSQLQINLFMVDHVCMMESSGNGHMCFCEEDMCN | ||||||
Disulfide bond | 41↔75 | |||||
Sequence: CYECDSWTDARCKDPFNYTALPRDQPPLMTCNGCC | ||||||
Disulfide bond | 44↔52 | |||||
Sequence: CDSWTDARC | ||||||
Glycosylation | 57 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 71↔93 | |||||
Sequence: CNGCCVKMVRHQRSPYEVVRRMC | ||||||
Disulfide bond | 108↔119 | |||||
Sequence: CMMESSGNGHMC | ||||||
Disulfide bond | 121↔126 | |||||
Sequence: CEEDMC | ||||||
Lipidation | 127 | GPI-anchor amidated asparagine | ||||
Sequence: N | ||||||
Propeptide | PRO_0000365459 | 128-158 | Removed in mature form | |||
Sequence: SSKNLHTNGCQLHLIPIAVAVSWLMGQLLSR |
Post-translational modification
N-glycosylated probably on Asn-57.
Keywords
- PTM
PTM databases
Expression
Tissue specificity
Expressed in mushroom body (at protein level); overlaps with expression of Sh/shaker and nicotinic acetylcholine receptor (nAChR) components also involved in sleep regulation. Expressed in the adult brain and head. Enriched in the mushroom body, anterior optic tubercle, superior protocerebrum, antennal nerve and visual projection neuron fibers projecting into the lobula plate of the optic lobe.
Interaction
Subunit
Interacts (via loop 2 of the three-fingered Ly-6 domain) with Sh/shaker; this interaction may stabilize both components of the complex and may be required for targeting or retention of Sh/shaker to neural cell projections. Interacts (via loop 2 of the three-fingered Ly-6 domain) with nAChRalpha3 and potentially other nicotinic acetylcholine receptors; this interaction is required for antagonism of nicotinic acetylcholine receptors.
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 54-67 | Loop 1; may be required for cell surface localization or be essential for protein folding | ||||
Sequence: DPFNYTALPRDQPP | ||||||
Region | 77-91 | Loop 2; required for interaction with Sh/shaker and nAChRalpha3/Nicotinic acetylcholine receptor alpha3 | ||||
Sequence: KMVRHQRSPYEVVRR |
Domain
Consists of a single Ly-6 domain, adopting a three finger fold stabilized by 5 disulfide bonds. The first loop contains a region essential for protein folding or that is required for localization to the cell surface. The second loop mediates protein-protein interactions.
Sequence similarities
Belongs to the quiver family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length158
- Mass (Da)18,124
- Last updated2008-09-02 v1
- ChecksumBF3E8327EC40A58F
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH954179 EMBL· GenBank· DDBJ | EDV56458.1 EMBL· GenBank· DDBJ | Genomic DNA |