B3NSF6 · QVR_DROER

Function

function

Bifunctional regulator of neuronal activity in the mushroom body, and possibly other regions of the brain, that acts as a signaling molecule required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Reduces neuronal excitability by enhancing Sh/shaker K+ channel activity; possibly by stabilizing Sh/shaker to increase protein levels, accelerating its activation kinetics, slowing C-type inactivation and enhancing recovery from inactivation. Specifically affects the A-type K+ current. Antagonizes nicotinic acetylcholine receptors (nAChRs) to reduce synaptic transmission, possibly by preventing their localization to the cell surface. Required for regulation of neuromuscular excitability and plasticity at neuromuscular junctions.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexternal side of plasma membrane
Cellular Componentmembrane raft
Cellular Componentplasma membrane
Molecular Functionacetylcholine receptor inhibitor activity
Molecular FunctionGPI anchor binding
Molecular Functionpotassium channel activator activity
Biological Processnegative regulation of membrane potential
Biological Processpositive regulation of circadian sleep/wake cycle, sleep
Biological Processregulation of circadian sleep/wake cycle, sleep
Biological Processregulation of synaptic transmission, cholinergic
Biological Processrhythmic process
Biological Processsleep

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    UPAR/Ly6 domain-containing protein qvr
  • Alternative names
    • Protein quiver
    • Protein sleepless

Gene names

    • Name
      qvr
    • Synonyms
      sss
    • ORF names
      GG20204

Organism names

  • Taxonomic identifier
  • Strain
    • Tucson 14021-0224.01
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    B3NSF6

Proteomes

Subcellular Location

Cell membrane
; Lipid-anchor, GPI-anchor
Membrane raft
; Lipid-anchor, GPI-anchor

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane136-156Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation, lipidation, propeptide.

TypeIDPosition(s)Description
Signal1-32
ChainPRO_000036545833-127UPAR/Ly6 domain-containing protein qvr
Disulfide bond41↔75
Disulfide bond44↔52
Glycosylation57N-linked (GlcNAc...) asparagine
Disulfide bond71↔93
Disulfide bond108↔119
Disulfide bond121↔126
Lipidation127GPI-anchor amidated asparagine
PropeptidePRO_0000365459128-158Removed in mature form

Post-translational modification

N-glycosylated probably on Asn-57.

Keywords

PTM databases

Expression

Tissue specificity

Expressed in mushroom body (at protein level); overlaps with expression of Sh/shaker and nicotinic acetylcholine receptor (nAChR) components also involved in sleep regulation. Expressed in the adult brain and head. Enriched in the mushroom body, anterior optic tubercle, superior protocerebrum, antennal nerve and visual projection neuron fibers projecting into the lobula plate of the optic lobe.

Interaction

Subunit

Interacts (via loop 2 of the three-fingered Ly-6 domain) with Sh/shaker; this interaction may stabilize both components of the complex and may be required for targeting or retention of Sh/shaker to neural cell projections. Interacts (via loop 2 of the three-fingered Ly-6 domain) with nAChRalpha3 and potentially other nicotinic acetylcholine receptors; this interaction is required for antagonism of nicotinic acetylcholine receptors.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region54-67Loop 1; may be required for cell surface localization or be essential for protein folding
Region77-91Loop 2; required for interaction with Sh/shaker and nAChRalpha3/Nicotinic acetylcholine receptor alpha3

Domain

Consists of a single Ly-6 domain, adopting a three finger fold stabilized by 5 disulfide bonds. The first loop contains a region essential for protein folding or that is required for localization to the cell surface. The second loop mediates protein-protein interactions.

Sequence similarities

Belongs to the quiver family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    158
  • Mass (Da)
    18,124
  • Last updated
    2008-09-02 v1
  • Checksum
    BF3E8327EC40A58F
MWTQRNAVGNWLLVLTAVIGFLTFIWIPQTSAECQTRSIYCYECDSWTDARCKDPFNYTALPRDQPPLMTCNGCCVKMVRHQRSPYEVVRRMCTSQLQINLFMVDHVCMMESSGNGHMCFCEEDMCNSSKNLHTNGCQLHLIPIAVAVSWLMGQLLSR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH954179
EMBL· GenBank· DDBJ
EDV56458.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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