B2S7B5 · DUT_BRUA1
- ProteinDeoxyuridine 5'-triphosphate nucleotidohydrolase
- Genedut
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids157 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Catalytic activity
- dUTP + H2O = dUMP + diphosphate + H+
Cofactor
Pathway
Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 76-78 | substrate | ||||
Sequence: RSG | ||||||
Binding site | 89 | substrate | ||||
Sequence: N | ||||||
Binding site | 93-95 | substrate | ||||
Sequence: TID | ||||||
Binding site | 103 | substrate | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | dUTP diphosphatase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | dUMP biosynthetic process | |
Biological Process | dUTP catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDeoxyuridine 5'-triphosphate nucleotidohydrolase
- EC number
- Short namesdUTPase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Brucellaceae > Brucella/Ochrobactrum group > Brucella
Accessions
- Primary accessionB2S7B5
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000094943 | 1-157 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | |||
Sequence: MTAASSSAPTLGIIRLEHAKGLDLPAYETAGSAGMDLRAAVAEDRQIVLLPGRRTLVPTGLILEIPQGYEVQIRPRSGLAFKNGITCLNTPGTIDSDYRGEVKVLLINLGDDDFRIERGMRIAQAVFAPVIQPKIEERAKISETARGAGGFGSTGTA |
Structure
Sequence
- Sequence statusComplete
- Length157
- Mass (Da)16,660
- Last updated2008-07-01 v1
- Checksum7C9BB78942CFADEF
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000887 EMBL· GenBank· DDBJ | ACD73062.1 EMBL· GenBank· DDBJ | Genomic DNA |