B1JQW4 · HLDD_YERPY
- ProteinADP-L-glycero-D-manno-heptose-6-epimerase
- GenehldD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids310 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
Catalytic activity
- ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose
Cofactor
Note: Binds 1 NADP+ per subunit.
Pathway
Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 10-11 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: FI | ||||||
Binding site | 31-32 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: DN | ||||||
Binding site | 38 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 53 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 75-79 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: EGACS | ||||||
Binding site | 92 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Active site | 140 | Proton acceptor | ||||
Sequence: Y | ||||||
Binding site | 144 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 169 | substrate | ||||
Sequence: N | ||||||
Binding site | 170 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Active site | 178 | Proton acceptor | ||||
Sequence: K | ||||||
Binding site | 178 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 180 | substrate | ||||
Sequence: S | ||||||
Binding site | 187 | substrate | ||||
Sequence: H | ||||||
Binding site | 201-204 | substrate | ||||
Sequence: FAGS | ||||||
Binding site | 209 | substrate | ||||
Sequence: R | ||||||
Binding site | 272 | substrate | ||||
Sequence: Y |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ADP-glyceromanno-heptose 6-epimerase activity | |
Molecular Function | NADP binding | |
Biological Process | ADP-L-glycero-beta-D-manno-heptose biosynthetic process | |
Biological Process | carbohydrate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameADP-L-glycero-D-manno-heptose-6-epimerase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Yersiniaceae > Yersinia
Accessions
- Primary accessionB1JQW4
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000148100 | 1-310 | ADP-L-glycero-D-manno-heptose-6-epimerase | |||
Sequence: MIIVTGGAGFIGSNIVKALNNIGYKDILVVDNLKDGTKFVNLVDLDIADYMDKEDFVASIVAGDDMGDIDAIFHEGACSSTTEWDGKYMMDNNYQYSKDILHFCLDRSIPFLYASSAATYGGRTDNFIEDRQYEQPLNVYGYSKFLFDQYVREILPQADSQICGFRYFNVYGPREGHKGSMASVAFHLNNQINAGERPKLFAGSENFKRDFIYVGDVADVNLWFWQNGVSGIFNCGTGRAESFQAVADAVVDYHQSGPVEYIEFPEKLKGRYQAYTQADLTKLRAAGYGKPFKTVAEGVKEYLAWLNRSV |
Interaction
Subunit
Homopentamer.
Structure
Sequence
- Sequence statusComplete
- Length310
- Mass (Da)34,780
- Last updated2008-04-29 v1
- ChecksumDB7A8D22860B5E28
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000950 EMBL· GenBank· DDBJ | ACA70405.1 EMBL· GenBank· DDBJ | Genomic DNA |