B1JQW4 · HLDD_YERPY

Function

function

Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.

Catalytic activity

Cofactor

NADP+ (UniProtKB | Rhea| CHEBI:58349 )

Note: Binds 1 NADP+ per subunit.

Pathway

Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site10-11NADP+ (UniProtKB | ChEBI)
Binding site31-32NADP+ (UniProtKB | ChEBI)
Binding site38NADP+ (UniProtKB | ChEBI)
Binding site53NADP+ (UniProtKB | ChEBI)
Binding site75-79NADP+ (UniProtKB | ChEBI)
Binding site92NADP+ (UniProtKB | ChEBI)
Active site140Proton acceptor
Binding site144NADP+ (UniProtKB | ChEBI)
Binding site169substrate
Binding site170NADP+ (UniProtKB | ChEBI)
Active site178Proton acceptor
Binding site178NADP+ (UniProtKB | ChEBI)
Binding site180substrate
Binding site187substrate
Binding site201-204substrate
Binding site209substrate
Binding site272substrate

GO annotations

AspectTerm
Molecular FunctionADP-glyceromanno-heptose 6-epimerase activity
Molecular FunctionNADP binding
Biological ProcessADP-L-glycero-beta-D-manno-heptose biosynthetic process
Biological Processcarbohydrate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ADP-L-glycero-D-manno-heptose-6-epimerase
  • EC number
  • Alternative names
    • ADP-L-glycero-beta-D-manno-heptose-6-epimerase
      (ADP-glyceromanno-heptose 6-epimerase
      ; ADP-hep 6-epimerase
      ; AGME
      )

Gene names

    • Name
      hldD
    • Ordered locus names
      YPK_4146

Organism names

Accessions

  • Primary accession
    B1JQW4

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001481001-310ADP-L-glycero-D-manno-heptose-6-epimerase

Interaction

Subunit

Homopentamer.

Structure

Family & Domains

Domain

Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    310
  • Mass (Da)
    34,780
  • Last updated
    2008-04-29 v1
  • Checksum
    DB7A8D22860B5E28
MIIVTGGAGFIGSNIVKALNNIGYKDILVVDNLKDGTKFVNLVDLDIADYMDKEDFVASIVAGDDMGDIDAIFHEGACSSTTEWDGKYMMDNNYQYSKDILHFCLDRSIPFLYASSAATYGGRTDNFIEDRQYEQPLNVYGYSKFLFDQYVREILPQADSQICGFRYFNVYGPREGHKGSMASVAFHLNNQINAGERPKLFAGSENFKRDFIYVGDVADVNLWFWQNGVSGIFNCGTGRAESFQAVADAVVDYHQSGPVEYIEFPEKLKGRYQAYTQADLTKLRAAGYGKPFKTVAEGVKEYLAWLNRSV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000950
EMBL· GenBank· DDBJ
ACA70405.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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