B1B4J2 · B1B4J2_ECOLX

  • Protein
    Histidine biosynthesis bifunctional protein HisIE
  • Gene
    hisI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

Catalytic activity

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionphosphoribosyl-AMP cyclohydrolase activity
Molecular Functionphosphoribosyl-ATP diphosphatase activity
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histidine biosynthesis bifunctional protein HisIE

Including 2 domains:

  • Recommended name
    Phosphoribosyl-AMP cyclohydrolase
  • EC number
  • Short names
    PRA-CH
  • Recommended name
    Phosphoribosyl-ATP pyrophosphatase
  • EC number
  • Short names
    PRA-PH

Gene names

    • Name
      hisI
    • Synonyms
      hisIE

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • TB182A
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    B1B4J2

Subcellular Location

Keywords

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-114Phosphoribosyl-AMP cyclohydrolase
Domain33-105Phosphoribosyl-AMP cyclohydrolase
Region115-203Phosphoribosyl-ATP pyrophosphohydrolase

Sequence similarities

In the C-terminal section; belongs to the PRA-PH family.
In the N-terminal section; belongs to the PRA-CH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    203
  • Mass (Da)
    22,857
  • Last updated
    2008-04-29 v1
  • Checksum
    D6CCCB74C3390485
MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTIESGKVTFFSRTKQRLWTKGETSGNFLNVVNITPDCDNDTLLLLANPIGPTCHKGTSSCFGDTTHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB453015
EMBL· GenBank· DDBJ
BAG11831.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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