B0K474 · ISPE_THEPX

Function

function

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

Catalytic activity

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site11
Binding site93-103ATP (UniProtKB | ChEBI)
Active site135

GO annotations

AspectTerm
Molecular Function4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity
Molecular FunctionATP binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
Biological Processphosphorylation
Biological Processterpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
  • EC number
  • Short names
    CMK
  • Alternative names
    • 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Gene names

    • Name
      ispE
    • Ordered locus names
      Teth514_0599

Organism names

Accessions

  • Primary accession
    B0K474

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10002023881-2894-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Structure

Family & Domains

Sequence similarities

Belongs to the GHMP kinase family. IspE subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    289
  • Mass (Da)
    32,214
  • Last updated
    2008-03-18 v1
  • Checksum
    21F1535A17DB0ECB
MKKIKVKAYAKINLSLDVLGKRKDGYHEISTVMQSIDLADILEFEKSEIVKVFCSGHRVPEGEDNLIVKVINFLKEKYQIEEGVLVRLDKKIPLAAGLAGGSADAAATIVALDKLWNLNMSADEKKEIALKVGADVPFCLEGGTKLAKGIGEIFEDLNVPHMNLLLVKPDIEIFTKKIYDKWDRLNFKSHHATCSVVQAIQEGNIYKIAENIKNDLELVTSRECEVINQIKEELLKKGALGCAMSGSGPTVYGIFDDLQKLIKAYKNLEGIYSFVFFSKTIDKGLELYE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000923
EMBL· GenBank· DDBJ
ABY91907.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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