B0K365 · PANB_THEPX

Function

function

Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site46Mg2+ (UniProtKB | ChEBI)
Binding site46-473-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site853-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site85Mg2+ (UniProtKB | ChEBI)
Binding site1153-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site117Mg2+ (UniProtKB | ChEBI)
Active site184Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Molecular Functionmagnesium ion binding
Biological Processpantothenate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-methyl-2-oxobutanoate hydroxymethyltransferase
  • EC number
  • Alternative names
    • Ketopantoate hydroxymethyltransferase
      (KPHMT
      )

Gene names

    • Name
      panB
    • Ordered locus names
      Teth514_0427

Organism names

Accessions

  • Primary accession
    B0K365

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000970141-2743-methyl-2-oxobutanoate hydroxymethyltransferase

Interaction

Subunit

Homodecamer; pentamer of dimers.

Structure

Family & Domains

Sequence similarities

Belongs to the PanB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    274
  • Mass (Da)
    29,988
  • Last updated
    2008-03-18 v1
  • Checksum
    758752D0F4E653B8
MEEKVSTLTLRKFKKEGRKITALTAYDFPTAKILDNCGIDMILVGDSLGMVVLGYESTIPVTMEDMIHHTKAVSRAVNRAFIVADMPFMSYHISKEQAMTNAARLIAEGGAHAVKLEGGEEIASIVKAIVDAGIPVVGHLGLTPQSVHQLGGYKVQGKEKEQAKKIFNDAKVLEQAGICALVLESIPMELAKNITENISVPTIGIGAGPYCDGQILVTHDMLGITQGHRPKFVKQYADIEKIMIDGINAYIKEVQQVLFPDEEHSFTLEKRENK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000923
EMBL· GenBank· DDBJ
ABY91737.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp