B0C6S1 · PANCY_ACAM1

Function

function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Catalyzes the transfer of a phosphate group from ATP to either CMP or dCMP to form CDP or dCDP and ADP, respectively.

Catalytic activity

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site44-51ATP (UniProtKB | ChEBI)
Active site51Proton donor
Binding site75(R)-pantoate (UniProtKB | ChEBI)
Binding site75beta-alanine (UniProtKB | ChEBI)
Binding site162-165ATP (UniProtKB | ChEBI)
Binding site168(R)-pantoate (UniProtKB | ChEBI)
Binding site191ATP (UniProtKB | ChEBI)
Binding site199-202ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular FunctionCMP kinase activity
Molecular FunctiondCMP kinase activity
Molecular Functionpantoate-beta-alanine ligase activity
Biological Processnucleobase-containing small molecule interconversion
Biological Processpantothenate biosynthetic process
Biological Processphosphorylation
Biological Processpyrimidine nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional pantoate ligase/cytidylate kinase

Including 2 domains:

  • Recommended name
    Pantothenate synthetase
  • EC number
  • Short names
    PS
  • Alternative names
    • Pantoate--beta-alanine ligase
    • Pantoate-activating enzyme
  • Recommended name
    Cytidylate kinase
  • EC number
  • Short names
    CK
  • Alternative names
    • Cytidine monophosphate kinase
      (CMP kinase
      )

Gene names

    • Name
      panC/cmk
    • Ordered locus names
      AM1_2620

Organism names

Accessions

  • Primary accession
    B0C6S1

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003332941-525Bifunctional pantoate ligase/cytidylate kinase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-292Pantoate--beta-alanine ligase
Region293-525Cytidylate kinase

Sequence similarities

In the N-terminal section; belongs to the pantothenate synthetase family.
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    525
  • Mass (Da)
    57,533
  • Last updated
    2008-02-26 v1
  • Checksum
    EE2A7EA486E0C84A
MDNVPIIRTVSGLRHFLRCFPGNLNTGASPSSTVIGQIGLVPTMGALHAGHLSLIQRARQENQCVIVSIFVNPLQFAAHEDLTEYPQTLNQDQALCQEQGVNTIFAPSTDTLLADAPLTQVIPPASLTEYLCGPHRPDHFTGVATIVLKLLNIVQPTRAYFGQKDAQQLAIIQRLVQDFNLDVTIVPCKLIRDATGLALSSRNQYLNAQEAQQATILHHSLQAARHTFQGGSCDRNSVLATVAQTLAKGPQVEVEYIDLVDPVTLQPLEQITTQGLVAIAARVGSARLIDNMLLDARLPILAIDGPAGAGKSTVTRRCAQAIGLQYLDTGAMYRAVAWLALDQQVEVSDPFAIADLVEDCQIELKPHADPQQQPQVWVNHQEVTQAIRTPDVTALVSAVAAQPPVREALVKQQQRLGRQGGLIAEGRDIGTNVFPDAGLKIFLTASIEERARRRQQDLKNQNLPPQTQSELEDLIASRDQQDSQREFAPLRKAYDAVEINTDGMTIEQVITRITTLYQERFPDRA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000828
EMBL· GenBank· DDBJ
ABW27627.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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