B0C6S1 · PANCY_ACAM1
- ProteinBifunctional pantoate ligase/cytidylate kinase
- GenepanC/cmk
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids525 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Catalyzes the transfer of a phosphate group from ATP to either CMP or dCMP to form CDP or dCDP and ADP, respectively.
Catalytic activity
- (R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H+
Pathway
Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 44-51 | ATP (UniProtKB | ChEBI) | ||||
Sequence: MGALHAGH | ||||||
Active site | 51 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 75 | (R)-pantoate (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 75 | beta-alanine (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 162-165 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GQKD | ||||||
Binding site | 168 | (R)-pantoate (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 191 | ATP (UniProtKB | ChEBI) | ||||
Sequence: I | ||||||
Binding site | 199-202 | ATP (UniProtKB | ChEBI) | ||||
Sequence: LSSR |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | CMP kinase activity | |
Molecular Function | dCMP kinase activity | |
Molecular Function | pantoate-beta-alanine ligase activity | |
Biological Process | nucleobase-containing small molecule interconversion | |
Biological Process | pantothenate biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | pyrimidine nucleotide metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional pantoate ligase/cytidylate kinase
Including 2 domains:
- Recommended namePantothenate synthetase
- EC number
- Short namesPS
- Alternative names
- Recommended nameCytidylate kinase
- EC number
- Short namesCK
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Acaryochloridales > Acaryochloridaceae > Acaryochloris
Accessions
- Primary accessionB0C6S1
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000333294 | 1-525 | Bifunctional pantoate ligase/cytidylate kinase | |||
Sequence: MDNVPIIRTVSGLRHFLRCFPGNLNTGASPSSTVIGQIGLVPTMGALHAGHLSLIQRARQENQCVIVSIFVNPLQFAAHEDLTEYPQTLNQDQALCQEQGVNTIFAPSTDTLLADAPLTQVIPPASLTEYLCGPHRPDHFTGVATIVLKLLNIVQPTRAYFGQKDAQQLAIIQRLVQDFNLDVTIVPCKLIRDATGLALSSRNQYLNAQEAQQATILHHSLQAARHTFQGGSCDRNSVLATVAQTLAKGPQVEVEYIDLVDPVTLQPLEQITTQGLVAIAARVGSARLIDNMLLDARLPILAIDGPAGAGKSTVTRRCAQAIGLQYLDTGAMYRAVAWLALDQQVEVSDPFAIADLVEDCQIELKPHADPQQQPQVWVNHQEVTQAIRTPDVTALVSAVAAQPPVREALVKQQQRLGRQGGLIAEGRDIGTNVFPDAGLKIFLTASIEERARRRQQDLKNQNLPPQTQSELEDLIASRDQQDSQREFAPLRKAYDAVEINTDGMTIEQVITRITTLYQERFPDRA |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-292 | Pantoate--beta-alanine ligase | ||||
Sequence: MDNVPIIRTVSGLRHFLRCFPGNLNTGASPSSTVIGQIGLVPTMGALHAGHLSLIQRARQENQCVIVSIFVNPLQFAAHEDLTEYPQTLNQDQALCQEQGVNTIFAPSTDTLLADAPLTQVIPPASLTEYLCGPHRPDHFTGVATIVLKLLNIVQPTRAYFGQKDAQQLAIIQRLVQDFNLDVTIVPCKLIRDATGLALSSRNQYLNAQEAQQATILHHSLQAARHTFQGGSCDRNSVLATVAQTLAKGPQVEVEYIDLVDPVTLQPLEQITTQGLVAIAARVGSARLIDNM | ||||||
Region | 293-525 | Cytidylate kinase | ||||
Sequence: LLDARLPILAIDGPAGAGKSTVTRRCAQAIGLQYLDTGAMYRAVAWLALDQQVEVSDPFAIADLVEDCQIELKPHADPQQQPQVWVNHQEVTQAIRTPDVTALVSAVAAQPPVREALVKQQQRLGRQGGLIAEGRDIGTNVFPDAGLKIFLTASIEERARRRQQDLKNQNLPPQTQSELEDLIASRDQQDSQREFAPLRKAYDAVEINTDGMTIEQVITRITTLYQERFPDRA |
Sequence similarities
In the N-terminal section; belongs to the pantothenate synthetase family.
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length525
- Mass (Da)57,533
- Last updated2008-02-26 v1
- ChecksumEE2A7EA486E0C84A
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000828 EMBL· GenBank· DDBJ | ABW27627.1 EMBL· GenBank· DDBJ | Genomic DNA |