A9VCQ2 · MTNB_MONBE
- ProteinProbable methylthioribulose-1-phosphate dehydratase
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids249 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
Catalytic activity
- S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | methylthioribulose 1-phosphate dehydratase activity | |
Molecular Function | zinc ion binding | |
Biological Process | L-methionine salvage from methylthioadenosine | |
Biological Process | L-methionine salvage from S-adenosylmethionine |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable methylthioribulose-1-phosphate dehydratase
- EC number
- Short namesMTRu-1-P dehydratase
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Choanoflagellata > Craspedida > Salpingoecidae > Monosiga
Accessions
- Primary accessionA9VCQ2
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000393858 | 1-249 | Probable methylthioribulose-1-phosphate dehydratase | |||
Sequence: MAAEPAALSARYFDDRYGPEHPRNLIPELCRLFYRNGWVTGTGGGISIKHEGKIYIAPSGVQKERIEPADFFVTDEAGTVLETPPADKMLKMSECTPLFMNAFTMRKAGACLHSHSPNAVLATMLCDKELRITNIEMIKGIRKASTGQSYGYYDTLVIPIIENTAREAELQSRMAACMEEYPDTCAVLVRRHGVYVWGDTWQKAKGMVECYDYLFEMFIRMKQLGLDPEQPDVNGAARAAEPDAKKAKQ |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 230-249 | Disordered | ||||
Sequence: QPDVNGAARAAEPDAKKAKQ |
Sequence similarities
Belongs to the aldolase class II family. MtnB subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length249
- Mass (Da)27,870
- Last updated2008-02-05 v1
- ChecksumEC001120EC9C6B2B
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH991582 EMBL· GenBank· DDBJ | EDQ84686.1 EMBL· GenBank· DDBJ | Genomic DNA |