A9MK49 · END4_SALAR

Function

function

Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.
    EC:3.1.21.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 3 Zn2+ ions.

Features

Showing features for binding site.

128520406080100120140160180200220240260280
TypeIDPosition(s)Description
Binding site69Zn2+ 1 (UniProtKB | ChEBI)
Binding site109Zn2+ 1 (UniProtKB | ChEBI)
Binding site145Zn2+ 1 (UniProtKB | ChEBI)
Binding site145Zn2+ 2 (UniProtKB | ChEBI)
Binding site179Zn2+ 2 (UniProtKB | ChEBI)
Binding site182Zn2+ 3 (UniProtKB | ChEBI)
Binding site216Zn2+ 2 (UniProtKB | ChEBI)
Binding site229Zn2+ 3 (UniProtKB | ChEBI)
Binding site231Zn2+ 3 (UniProtKB | ChEBI)
Binding site261Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functiondeoxyribonuclease IV (phage-T4-induced) activity
Molecular FunctionDNA binding
Molecular Functionzinc ion binding
Biological ProcessDNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable endonuclease 4
  • EC number
  • Alternative names
    • Endodeoxyribonuclease IV
    • Endonuclease IV

Gene names

    • Name
      nfo
    • Ordered locus names
      SARI_00686

Organism names

Accessions

  • Primary accession
    A9MK49

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000768071-285Probable endonuclease 4

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the AP endonuclease 2 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    285
  • Mass (Da)
    31,207
  • Last updated
    2008-02-05 v1
  • Checksum
    87DFE8E949F18696
MKYIGAHVSAAGGLANAPARAAEIGATAFALFTKNQRQWRAAPLIPQVIDDFKIACEKYHFSAAQILPHDSYLINLGHPVSEALEKSRDAFLDEMQRCEQLGLTLLNFHPGSHLMQIAQEDCLARIAESINIALAQTEGVTAVIENTAGQGSNLGFEFEQLAAIIDGVEDKSRVGVCIDTCHAFAAGYDLRTPEACEKTFAEFGQIVGFQYLRGMHLNDAKSAFGSRVDRHHSLGEGNIGHDAFRWIMQDARFDGIPLVLETINPDIWAEEIAWLKAQQSEKAVA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000880
EMBL· GenBank· DDBJ
ABX20609.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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