A9KWX0 · COAD_SHEB9
- ProteinPhosphopantetheine adenylyltransferase
- GenecoaD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids163 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Catalytic activity
- (R)-4'-phosphopantetheine + ATP + H+ = 3'-dephospho-CoA + diphosphate
Cofactor
Pathway
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 10 | substrate | ||||
Sequence: T | ||||||
Binding site | 10-11 | ATP (UniProtKB | ChEBI) | ||||
Sequence: TF | ||||||
Binding site | 18 | ATP (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Site | 18 | Transition state stabilizer | ||||
Sequence: H | ||||||
Binding site | 42 | substrate | ||||
Sequence: K | ||||||
Binding site | 74 | substrate | ||||
Sequence: L | ||||||
Binding site | 88 | substrate | ||||
Sequence: R | ||||||
Binding site | 89-91 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GLR | ||||||
Binding site | 99 | ATP (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 124-130 | ATP (UniProtKB | ChEBI) | ||||
Sequence: NSFISST |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | pantetheine-phosphate adenylyltransferase activity | |
Biological Process | coenzyme A biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphopantetheine adenylyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Alteromonadales > Shewanellaceae > Shewanella
Accessions
- Primary accessionA9KWX0
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000076786 | 1-163 | Phosphopantetheine adenylyltransferase | |||
Sequence: MHTRAIYPGTFDPITNGHADLIERAAKLFKHVIIGIAANPSKQPRFTLEERVELVNRVTAHLDNVEVVGFSGLLVDFAKEQKASVLVRGLRAVSDFEYEFQLANMNRRLSPDLESVFLTPAEENSFISSTLVKEVALHGGDVSQFVHSEVATALAAKLKLAKP |
Interaction
Subunit
Homohexamer.
Structure
Sequence
- Sequence statusComplete
- Length163
- Mass (Da)17,953
- Last updated2008-02-05 v1
- ChecksumFF4C4BAF173EA412
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000891 EMBL· GenBank· DDBJ | ABX51628.1 EMBL· GenBank· DDBJ | Genomic DNA |