A8BCK6 · AGO_GIAIC

Function

function

Plays an essential role in growth and, with Dicer, also involved in microRNA (miRNA)-mediated translational repression. The RNA interference pathway is implicated in antigenic variation having a role in regulation of variant-specific surface protein (VSP)-coding gene expression. Several VSP genes are transcribed but only transcripts encoding the VSP to be expressed accumulate. Antisense RNAs corresponding to the silenced VSP genes are detected (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular FunctionRNA binding
Biological Processcell differentiation
Biological Processregulation of translation
Biological Processregulatory ncRNA-mediated gene silencing

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein argonaute

Gene names

    • Name
      Ago
    • ORF names
      GL50803_2902

Organism names

Accessions

  • Primary accession
    A8BCK6

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004052351-900Protein argonaute

Interaction

Subunit

Interacts with miR2. Highly specific binding to the mRNA m7G-cap. May be a component of the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain229-313PAZ
Domain555-879Piwi

Domain

PAZ domain is absent, but Ago is capable of binding small RNAs in the same way as the other Argonaute proteins.

Sequence similarities

Belongs to the argonaute family. Ago subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    900
  • Mass (Da)
    100,817
  • Last updated
    2007-11-13 v1
  • Checksum
    4B9D91A0E8136F45
MVADVVTSRINFYPYTVLPSARPVYQYDLSIHISNQGYSLDNADSCRALERFCEQQDAALGNNLEHGLFYSLIIDFPSSDACPISSFYSQIDLGSRPITHTVEFLSTQKPRRRGGRVGGMRNNIAGPPITPVQATVKVTRVRQMDPTDLMSMKILLNILLRRTFESSLGMLNIRSGFYDLRNPSIHAIQIDGRGYDICWIPGFRLTTATLRGKLGLQILPETTKVRSKSMNELLTERRGNIHPSALAVITVMAMHNGKVFRVHSIVQGQTIVSPLANGNETDYFTYYSTRYRDKIDSAGLSLLRHNDYCNSVMQQDKFILKLTPLKRTQNGKVVRPCNVPSSLCIIISDNEIAPYGVSKLSTNRAAVALSTMSPDALLEKATAFAARLAEDTELQSLLGDYGFGFTSNPLELETFVCKPPKLMMDNTSRIVTIEDDSGGVFHNLLQSPGVSPIYYSNNNQPATGMPVWAIMVPRNLGNDYARRLRKELTERVRSLAGTTAPNIGDPPLIAVELSNQRREMYRVEPYKDAFKALLNKLRLEYKDARESEIVAKIQLVVIVIPGPKQDRGDLYKGIKQFYTHMGIVTQCLLAPKSSQNELQWYDQAVLRSVCQQIYAKAGGAVWAPVLPPQNVYSKSTMLCALDISRPKKTVGRPAEVPISTAGFISTYDGSFEYIYSQKKTLVPNRLNHGGELQQQTLMEAFIKNSCNVYLAFNNRILPDHIVIFRDGVSDSQISATLEVEIKSLYECLRQIYHKSNRPMCDLKVIVAQKTCAMRFSAVGGTVLRSGYYVINRSPDNRQQGSEFLMASQAIVHGTTPKPIRYKIIFDSMEASVDNDSFNQLIELTNAMAYGYVNWPQAISLPHVLHMAHHLSKFCGEVLRNGDDLFESCAIFGLQYRPFFI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AACB02000011
EMBL· GenBank· DDBJ
EDO80252.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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